ma:nyo Bifida Biome Complex Ampoule

ma:nyo Bifida Biome Complex Ampoule
5.1
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.2 Occlusivity icon Occlusivity
5.2Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers

Review

Results you may expect from using ma:nyo Bifida Biome Complex Ampoule:

Based on the ingredient analysis by CreamScan, these are the key benefits you can expect from using ma:nyo Bifida Biome Complex Ampoule:

  • Moderate moisturizing. It has a moisturizing rating of 5.1 out of 10.
  • Considerable anti-wrinkle efficacy: ma:nyo Bifida Biome Complex Ampoule has an anti-wrinkle rating of 5.2 out of 10, indicating a moderate ability to reduce wrinkles.
  • Soothing: ma:nyo Bifida Biome Complex Ampoule contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
  • Antioxidant protection.

How moisturizing is it?

Quite moisturizing: ma:nyo Bifida Biome Complex Ampoule has a moisturizing rating of 5.1 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.2 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Butylene Glycol (est. ≈22.0%), Saccharomyces Ferment Filtrate (est. ≈3.0%) and Glycerin (est. ≈2.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, ma:nyo Bifida Biome Complex Ampoule has a moderate anti-wrinkle rating of 5.2 out of 10.

It contains 2 active ingredients with proven anti-wrinkle efficacy:

  • Asiaticoside (est. ≈0.3%),
     derived from the plant Centella asiatica, an ingredient with moderate anti-wrinkle efficacy confirmed by one study.
  • Niacinamide (est. ≈1.5%),
     one of the most effective and well-researched anti-wrinkle ingredients.
Among others, ma:nyo Bifida Biome Complex Ampoule also contains some ingredients marketed as effective in reducing wrinkles, specifically Leontopodium Alpinum Callus Culture Extract, Asiatic Acid, Madecassic Acid, Copper Tripeptide-1, Acetyl Hexapeptide-8, Caffeine, and Adenosine. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, could deliver additional anti-wrinkle efficacy through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Antioxidant benefits

We estimate that ma:nyo Bifida Biome Complex Ampoule is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈1.5%), Hyaluronic Acid (est. ≈0.3%), Sodium Hyaluronate (est. ≈0.3%), and others.

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Skin soothing

Based on the ingredient list analysis, ma:nyo Bifida Biome Complex Ampoule is rich (> 5%) in soothing ingredients, particularly Bifida Ferment Lysate (est. ≈40.0%) and Saccharomyces Ferment Filtrate (est. ≈3.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

Ingredients

Est. % Ingredient Origin Functions
40
Bifida Ferment Lysate
22
Butylene Glycol
11
Bifida Ferment Filtrate
6
Lactobacillus Ferment Lysate
4
Lactococcus Ferment Lysate
3
Saccharomyces Ferment Filtrate
2
Glycerin
1.5
Niacinamide
1
1,2-Hexanediol
0.3
Lactobacillus/Pumpkin Fruit Ferment Filtrate
0.3
Aureobasidium Pullulans Ferment
0.3
Hyaluronic Acid
0.3
Sodium Hyaluronate
0.3
Sodium Hyaluronate Crosspolymer
0.3
Sodium Acetylated Hyaluronate
0.3
Hydrolyzed Sodium Hyaluronate
0.3
Potassium Hyaluronate
0.3
Hydrolyzed Hyaluronic Acid
0.3
Hydroxypropyltrimonium Hyaluronate
0.3
Leontopodium Alpinum Callus Culture Extract
0.3
Cutibacterium Granulosum Ferment Extract Filtrate
0.3
Asiaticoside
0.3
Asiatic Acid
0.3
Madecassic Acid
0.3
Pentylene Glycol
0.3
Squalane
0.3
Hydrogenated Lecithin
0.3
Copper Tripeptide-1
0.3
Tromethamine
0.3
Acetyl Hexapeptide-8
0.3
Propanediol
0.3
Ethylhexylglycerin
0.3
Dextrin
0.3
Water
0.3
Caffeine
0.3
Benzyl Glycol
0.3
Sodium Phytate
0.3
Hydrolyzed Algin
0.3
Xanthan Gum
0.3
Epigallocatechin Gallate
0.3
Carbomer
0.3
Physalis Alkekengi Calyx Extract
0.3
Hydrolyzed Glycosaminoglycans
0.3
Polyglyceryl-10 Laurate
0.3
Theobroma Cacao (Cocoa) Seed Extract
0.3
Adenosine
Est. %
Bifida Ferment Lysate
Function:
Origin:
Butylene Glycol
Function:
Origin:
Bifida Ferment Filtrate
Function:
Origin:
Lactobacillus Ferment Lysate
Function:
Origin:
Lactococcus Ferment Lysate
Function:
Origin:
Saccharomyces Ferment Filtrate
Function:
Origin:
Glycerin
Function:
Origin:
Niacinamide
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Lactobacillus/Pumpkin Fruit Ferment Filtrate
Function:
Origin:
Aureobasidium Pullulans Ferment
Function:
Origin:
Hyaluronic Acid
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Sodium Hyaluronate Crosspolymer
Function:
Origin:
Sodium Acetylated Hyaluronate
Function:
Origin:
Hydrolyzed Sodium Hyaluronate
Function:
Origin:
Potassium Hyaluronate
Function:
Origin:
Hydrolyzed Hyaluronic Acid
Function:
Origin:
Hydroxypropyltrimonium Hyaluronate
Function:
Origin:
Leontopodium Alpinum Callus Culture Extract
Function:
Origin:
Cutibacterium Granulosum Ferment Extract Filtrate
Function:
Origin:
Asiaticoside
Function:
Origin:
Asiatic Acid
Function:
Origin:
Madecassic Acid
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Squalane
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Copper Tripeptide-1
Function:
Origin:
Tromethamine
Function:
Origin:
Acetyl Hexapeptide-8
Function:
Origin:
Propanediol
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Dextrin
Function:
Origin:
Water
Function:
Origin:
Caffeine
Function:
Origin:
Benzyl Glycol
Function:
Origin:
Sodium Phytate
Function:
Origin:
Hydrolyzed Algin
Function:
Origin:
Xanthan Gum
Function:
Origin:
Epigallocatechin Gallate
Function:
Origin:
Carbomer
Function:
Origin:
Physalis Alkekengi Calyx Extract
Function:
Origin:
Hydrolyzed Glycosaminoglycans
Function:
Origin:
Polyglyceryl-10 Laurate
Function:
Origin:
Theobroma Cacao (Cocoa) Seed Extract
Function:
Origin:
Adenosine
Function:
Origin:

Ratings

All humectants
32.1
22
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.3
0.3
Benchmark
20
Moisturizing rating
5.1
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 32.1 10
10.0
22
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.3 20
0.2
0.3
Moisturizing rating
5.1
Ingredient Est. % Benchmark Humectancy
22
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 32.1 10
10
All humectants
32.1
22
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
All occlusives 0.3 20
0.2
All occlusives
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
3 /10 0.1 0.3 3
6 /10 4 1.5 2.2
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
5.2
Asiaticoside
3
Ingredient anti-wrinkle power
3 /10
when present at, %
0.1
in this formula, est. %
0.3
Niacinamide
2.2
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
1.5
Leontopodium Alpinum Callus Culture Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Asiatic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Madecassic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Copper Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Hexapeptide-8
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Caffeine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
5.2
Ingredient Est. % Benchmark
Rich in Antioxidants
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 4.8 3 Rich in antioxidants
All antioxidants
4.8
Niacinamide
1.5
Asiaticoside
0.3
Hyaluronic Acid
0.3
Sodium Hyaluronate
0.3
Hydrolyzed Sodium Hyaluronate
0.3
Hydrolyzed Hyaluronic Acid
0.3
Leontopodium Alpinum Callus Culture Extract
0.3
Copper Tripeptide-1
0.3
Caffeine
0.3
Hydrolyzed Algin
0.3
Epigallocatechin Gallate
0.3
Theobroma Cacao (Cocoa) Seed Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
40
3
1.5
0.3
0.3
0.3
All soothing 45.4 5 Rich in soothing
All soothing
45.4
40
3
1.5
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Bifida Ferment Lysate
Est. %40
Function
Origin
Bifida Ferment LysateA mixture of probiotic bacteria. According to the patent holder, it contains enzymes that are able to repair damaged DNA in skin cells. A single study confirms that it is able to reduce skin sensitivity.
Butylene Glycol
Est. %22
Function
Origin
Butylene GlycolA clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.
Bifida Ferment Filtrate
Est. %11
Function
Origin
Bifida Ferment Filtrate
Lactobacillus Ferment Lysate
Est. %6
Function
Origin
Lactobacillus Ferment Lysate
Lactococcus Ferment Lysate
Est. %4
Function
Origin
Lactococcus Ferment LysateA relatively new probiotic ingredient. Various patents claim its moisturizing properties and in one study it was shown to improve skin barrier function.
Saccharomyces Ferment Filtrate
Est. %3
Function
Origin
Saccharomyces Ferment FiltrateA yeast mixture that contains humectant moisturizing amino acids, nucleic acids (building blocks of DNA), peptides, various minerals, and vitamins.
Glycerin
Est. %2
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Niacinamide
Est. %1.5
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

1,2-Hexanediol
Est. %1
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Lactobacillus/Pumpkin Fruit Ferment Filtrate
Est. %0.3
Function
Origin
Lactobacillus/Pumpkin Fruit Ferment Filtrate
Aureobasidium Pullulans Ferment
Est. %0.3
Function
Origin
Aureobasidium Pullulans Ferment
Hyaluronic Acid
Est. %0.3
Function
Origin
Hyaluronic Acid

A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.

Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Sodium Hyaluronate Crosspolymer
Est. %0.3
Function
Origin
Sodium Hyaluronate CrosspolymerA modified version of regular hyaluronic acid. It attracts large volumes of water, thereby making it an effective humectant moisturizing ingredient.
Sodium Acetylated Hyaluronate
Est. %0.3
Function
Origin
Sodium Acetylated HyaluronateA chemically modified version of hyaluronic acid. It is more stable and less sticky than regular HA, while still providing the same humectant moisturizing properties (according to the manufacturer). There have been no clinical studies to confirm this.
Hydrolyzed Sodium Hyaluronate
Est. %0.3
Function
Origin
Hydrolyzed Sodium HyaluronateA very small-molecule version of regular sodium hyaluronate. It is a powerful humectant skin-identical ingredient that absorbs into the skin and offers plumping, smoothing, and anti-wrinkle effects.
Potassium Hyaluronate
Est. %0.3
Function
Origin
Potassium Hyaluronate
Hydrolyzed Hyaluronic Acid
Est. %0.3
Function
Origin
Hydrolyzed Hyaluronic AcidA smaller-molecule version of the regular hyaluronic acid. It is a powerful humectant that absorbs into the skin and offers moisturizing, smoothing, and anti-wrinkle effects. It is also slightly anti-inflammatory and displays subtle antioxidant properties.
Hydroxypropyltrimonium Hyaluronate
Est. %0.3
Function
Origin
Hydroxypropyltrimonium Hyaluronate
Leontopodium Alpinum Callus Culture Extract
Est. %0.3
Function
Origin
Leontopodium Alpinum Callus Culture ExtractPlant cells of the Edelweiss flower are grown into a so-called callus culture in order to extract active compounds of the plant. One of the compounds is leontopodic acid, which has antioxidant, antibacterial, and soothing effects.
Cutibacterium Granulosum Ferment Extract Filtrate
Est. %0.3
Function
Origin
Cutibacterium Granulosum Ferment Extract Filtrate
Asiaticoside
Est. %0.3
Function
Origin
Asiaticoside

A Gotu Kola or Centella Asiatica derivative with confirmed anti-wrinkle efficacy.

Asiatic Acid
Est. %0.3
Function
Origin
Asiatic AcidA compound isolated from Gotu Kola, a promising anti-wrinkle medicinal plant from Southeast Asia. It is claimed to increase the production of collagen and help with the wound healing process.
Madecassic Acid
Est. %0.3
Function
Origin
Madecassic AcidAn isolated bioactive compound from Gotu Kola. It increases collagen and hyaluronic acid production in the skin and helps to treat wounds, scars, and burns.
Pentylene Glycol
Est. %0.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Squalane
Est. %0.3
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Copper Tripeptide-1
Est. %0.3
Function
Origin
Copper Tripeptide-1

A skin-identical, copper-binding peptide that promotes the synthesis of all structural elements in the skin.

Tromethamine
Est. %0.3
Function
Origin
TromethamineAn ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level.
Acetyl Hexapeptide-8
Est. %0.3
Function
Origin
Acetyl Hexapeptide-8

A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way.

Propanediol
Est. %0.3
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Dextrin
Est. %0.3
Function
Origin
DextrinA partially hydrolyzed potato starch, most commonly used as a viscosity controlling and binding agent. When dispersed into water, it can create textures ranging from a thick paste to a soft gel.
Water
Est. %0.3
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Caffeine
Est. %0.3
Function
Origin
CaffeineAn antioxidant compound that is obtained from coffee and tea leaves. It increases the microcirculation of blood in the skin and is claimed to be able to reduce the appearance of orange peel skin (although the research is lacking).
Benzyl Glycol
Est. %0.3
Function
Origin
Benzyl Glycol
Sodium Phytate
Est. %0.3
Function
Origin
Sodium PhytateSodium phytate is a chelating agent that serves to remove heavy metal ions from water. Removing metal ions helps other ingredients, such as antioxidants and preservatives, to perform better and keep products from separating.
Hydrolyzed Algin
Est. %0.3
Function
Origin
Hydrolyzed AlginA humectant moisturizing mixture of algae-based polysaccharides, also known as alginate, that have undergone the process of hydrolysis.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Epigallocatechin Gallate
Est. %0.3
Function
Origin
Epigallocatechin GallateA bioactive compound isolated from green tea with numerous beneficial effects. It is an astringent and antioxidant and can help the skin to heal, reduce redness, and treat UV-induced damage.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Physalis Alkekengi Calyx Extract
Est. %0.3
Function
Origin
Physalis Alkekengi Calyx Extract
Hydrolyzed Glycosaminoglycans
Est. %0.3
Function
Origin
Hydrolyzed Glycosaminoglycans
Polyglyceryl-10 Laurate
Est. %0.3
Function
Origin
Polyglyceryl-10 LaurateA vegetable glycerin or synthetically produced emulsifier and gentle cleansing agent. It won't leave skin feeling tight or dry when used to cleanse.
Theobroma Cacao (Cocoa) Seed Extract
Est. %0.3
Function
Origin
Theobroma Cacao (Cocoa) Seed ExtractA cocoa beans extract that contains caffeine and astringent and antioxidant flavonols and tannins.
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.