iS Clinical GeneXC Serum Review

iS Clinical GeneXC Serum
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
Rich
in Antioxidants
Review

Does iS Clinical GeneXC Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what iS Clinical GeneXC Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
✅ Antioxidant protection

  

Key Benefits of iS Clinical GeneXC Serum

 
These are the key benefits you can expect from using iS Clinical GeneXC Serum:
 

🔵 Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, iS Clinical GeneXC Serum is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Pentylene Glycol (est. ≈4.0%) and Trehalose (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that iS Clinical GeneXC Serum is rich (> 3%) in antioxidants, specifically Ascorbyl Glucoside (est. ≈6.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: iS Clinical GeneXC Serum

 
CreamScan AI identified a few things to consider before adding iS Clinical GeneXC Serum to your skincare routine:
 

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using iS Clinical GeneXC Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

⚠️ Questionable anti-wrinkle efficacy

If one of your main reasons for choosing iS Clinical GeneXC Serum is its potential anti-aging effects, please note that, according to CreamScan analysis, it currently has a zero anti-wrinkle rating.

It contains Ascorbyl Glucoside and Camellia Sinensis Leaf Extract, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.

While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.

Therefore, these ingredients do not generate the anti-wrinkle rating.

📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Pros & Cons of iS Clinical GeneXC Serum

 
Here’s an overview of the pros and cons of iS Clinical GeneXC Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants
⚠️ Questionable anti-wrinkle efficacy
   

Summary: iS Clinical GeneXC Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that iS Clinical GeneXC Serum
, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
With its high antioxidant content, iS Clinical GeneXC Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about iS Clinical GeneXC Serum worth noting.
 
Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.
 
If one of your main reasons for considering iS Clinical GeneXC Serum is its potential anti-aging effects, please note that, according to CreamScan analysis, its anti-wrinkle efficacy is questionable. None of the ingredients in this product provide substantial evidence of their anti-wrinkle efficacy according to CreamScan Research Evaluation Standards.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredients

Est. % Ingredient Origin Functions
80
6
4
2
1.9
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Ascorbyl Glucoside
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Trehalose
Function:
Origin:
Glycerin
Function:
Origin:
Hydrolyzed Eruca Sativa Leaf
Function:
Origin:
Butylene Glycol
Function:
Origin:
Saccharum Officinarum (Sugarcane) Extract
Function:
Origin:
Citrus Limon (Lemon) Fruit Extract
Function:
Origin:
Citrus Aurantium Dulcis (Orange) Fruit Extract
Function:
Origin:
Pyrus Malus (Apple) Fruit Extract
Function:
Origin:
Camellia Sinensis Leaf Extract
Function:
Origin:
Terminalia Ferdinandiana Fruit Extract
Function:
Origin:
Acetyl Tyrosine
Function:
Origin:
Proline
Function:
Origin:
Hydrolyzed Vegetable Protein
Function:
Origin:
Adenosine Triphosphate
Function:
Origin:
Plankton Extract
Function:
Origin:
Arginine Ferulate
Function:
Origin:
Sucrose
Function:
Origin:
Lecithin
Function:
Origin:
Ethylbisiminomethylguaiacol Manganese Chloride
Function:
Origin:
Phenoxyethanol
Function:
Origin:

Ratings

All humectants
12.3
4
2
1.9
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 12.3 10
10.0
4
2
1.9
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
4
2
1.9
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 12.3 10
10
All humectants
12.3
4
2
1.9
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 6 -
n/a
- 0.3 -
Total
0
Ascorbyl Glucoside
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
6
Camellia Sinensis Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
6
1.5
1
0.3
0.3
0.3
0.3
0.3
All antioxidants 10 3 Rich in antioxidants
All antioxidants
10
Ascorbyl Glucoside
6
Hydrolyzed Eruca Sativa Leaf
1.5
Saccharum Officinarum (Sugarcane) Extract
1
Citrus Aurantium Dulcis (Orange) Fruit Extract
0.3
Pyrus Malus (Apple) Fruit Extract
0.3
Camellia Sinensis Leaf Extract
0.3
Terminalia Ferdinandiana Fruit Extract
0.3
Ethylbisiminomethylguaiacol Manganese Chloride
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
All soothing 0.6 5 No
All soothing
0.6
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %80
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Ascorbyl Glucoside
Est. %6
Function
Origin
Ascorbyl GlucosideA derivative of vitamin C. It is more stable and less irritating than ascorbic acid. There are unfortunately no clinical studies on ascorbyl glucoside’s anti-pigment or anti-acne efficacy alone.
Pentylene Glycol
Est. %4
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Trehalose
Est. %2
Function
Origin
TrehaloseA sweet-tasting saccharide that can be found in various yeasts and fungi and that is manufactured from starch for cosmetic purposes. It is one of the most popular sugars in skincare and is mainly used for its humectant properties.
Glycerin
Est. %1.9
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Hydrolyzed Eruca Sativa Leaf
Est. %1.5
Function
Origin
Hydrolyzed Eruca Sativa Leaf
Butylene Glycol
Est. %1.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Saccharum Officinarum (Sugarcane) Extract
Est. %1
Function
Origin
Saccharum Officinarum (Sugarcane) ExtractAn antioxidant extract from sugarcane, the famous crop used to make sugar. It acts as a humectant and exfoliating agent – the little sugar crystals mechanically remove dead skin cells from the skin’s surface.
Citrus Limon (Lemon) Fruit Extract
Est. %0.3
Function
Origin
Citrus Limon (Lemon) Fruit Extract

A fragrant extract from lemon peels that contains various antioxidant flavonoids, organic acids, and limonoids – which are currently under investigation as potential anti-wrinkle and anti-pigment compounds.

Citrus Aurantium Dulcis (Orange) Fruit Extract
Est. %0.3
Function
Origin
Citrus Aurantium Dulcis (Orange) Fruit Extract

An extract from the fruit of the sweet orange. It contains fragrant sweet orange essential oil, high amounts of antioxidant flavonoids (mainly hesperidin), and carotenoids – which give it the orange color.

Pyrus Malus (Apple) Fruit Extract
Est. %0.3
Function
Origin
Pyrus Malus (Apple) Fruit ExtractAn extract derived from apple fruit that has humectant moisturizing and antioxidant properties, as well as gentle anti-pigment effects. It contains humectant sugars, anti-pigment organic acids, and flavonoids.
Camellia Sinensis Leaf Extract
Est. %0.3
Function
Origin
Camellia Sinensis Leaf Extract

An antioxidant green tea extract. In the deeper layers, it slows down the destruction of collagen, elastin, and hyaluronic acid – thus delaying the signs of aging. It also acts as an anti-acne, soothing, moisturizing, and emollient ingredient.

Terminalia Ferdinandiana Fruit Extract
Est. %0.3
Function
Origin
Terminalia Ferdinandiana Fruit ExtractExtracted from the fruits of the Kakadu plum (which is the richest source of vitamin C among all plants) this ingredient acts as an excellent antioxidant. Besides this, it is also an antimicrobial agent with some humectant properties.
Acetyl Tyrosine
Est. %0.3
Function
Origin
Acetyl TyrosineAcetyl tyrosine is a derivative of the amino acid tyrosine. It is used as a tanning agent in skincare, helping pigment cells (melanosomes) to produce more dark skin pigment.
Proline
Est. %0.3
Function
Origin
ProlineThe best humectant moisturizer of all the amino acids. It is a part of the skin's Natural Moisturizing Factor and increases hydration in the top layers of the skin. It also has antioxidant activity and helps to heal damaged skin.
Hydrolyzed Vegetable Protein
Est. %0.3
Function
Origin
Hydrolyzed Vegetable ProteinA blanket term used for plant-based proteins that have been processed into smaller chunks. They add to the skincare product's film-forming and water-binding properties.
Adenosine Triphosphate
Est. %0.3
Function
Origin
Adenosine TriphosphateA cellular energy source that is thought to revitalize skin cells.
Plankton Extract
Est. %0.3
Function
Origin
Plankton ExtractAn extract from a mixture of various tiny marine animals, algae, seaweeds, and microscopic organisms jointly called plankton. One patent refers to it as a moisturizing humectant ingredient.
Arginine Ferulate
Est. %0.3
Function
Origin
Arginine Ferulate
Sucrose
Est. %0.3
Function
Origin
SucroseThis ingredient is more commonly known as table sugar or saccharose and is derived from sugar beets or sugar cane. It is used as a humectant moisturizing ingredient in skincare products, as well as a sweetener.
Lecithin
Est. %0.3
Function
Origin
LecithinA humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Ethylbisiminomethylguaiacol Manganese Chloride
Est. %0.3
Function
Origin
Ethylbisiminomethylguaiacol Manganese Chloride
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.