iS Clinical Extreme Protect SPF 40 Review

iS Clinical Extreme Protect SPF 40
6.8
/ 10
Moisturizing
9.2 Humectancy icon Humectancy
4.3 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
40
SPF icon
SPF
Review

Does iS Clinical Extreme Protect SPF 40 Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what iS Clinical Extreme Protect SPF 40 has to offer:
 
  • Significant moisturizing. It has a moisturizing rating of 6.8 out of 10.
  • Modest anti-wrinkle efficacy: iS Clinical Extreme Protect SPF 40 has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.
  • High sun protection for extended outdoor activities and exposure.

Key Benefits of iS Clinical Extreme Protect SPF 40

 
These are the key benefits you can expect from using iS Clinical Extreme Protect SPF 40:
 

Perfect Moisturizer for Normal to Dry Skin with a Balanced Texture, Neither Too Light nor Too Heavy

According to CreamScan analysis, iS Clinical Extreme Protect SPF 40 is highly moisturizing, with a moisturizing rating of 6.8 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a very high humectancy of 9.2 out of 10, primarily due to the substantial concentration of Glycerin (est. ≈6.0%) and Pentylene Glycol (est. ≈2.0%), and a moderate occlusivity of 4.3 out of 10, mainly due to the significant content of Caprylic/Capric Triglyceride (est. ≈4.0%) and Tocopherol (est. ≈3.0%).

This type of moisturizer is ideal for people with normal skin who want maximum hydration in a formula with a balanced texture - neither too light nor too heavy. It combines a high concentration of humectants with a significant amount of occlusive ingredients to deliver effective dual-action moisturizing for normal skin.

This product may also be a good choice for people with normal to dry skin for daily hydration, as it balances significant moisturizing potential with a balanced texture, neither too light nor too heavy.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, iS Clinical Extreme Protect SPF 40 has a modest level of anti-wrinkle efficacy, rated 3.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Asiaticoside (est. ≈0.3%), 
 derived from the plant Centella asiatica, an ingredient with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 27 participants (Lee et al.). This study demonstrated that a cream containing 0.1% asiaticoside reduced the average wrinkle depth by 8% after 12 weeks of use, compared to a vehicle (the same formulation without asiaticoside).
 
Among others, iS Clinical Extreme Protect SPF 40 also contains some ingredients marketed often as effective in reducing wrinkles, specifically Asiatic Acid, Madecassic Acid, and Olea Europaea (Olive) Leaf Extract. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that iS Clinical Extreme Protect SPF 40 is rich (> 3%) in antioxidants, specifically Tocopherol (est. ≈3.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

High Sun Protection for Extended Outdoor Activities and Exposure

With an SPF of 40, iS Clinical Extreme Protect SPF 40 provides high sun protection, making it ideal for prolonged outdoor activities such as hiking, gardening, sports, or spending time at the beach.

This level of SPF blocks up to 98% of UVB rays, significantly reducing the risk of sunburn. When formulated as broad-spectrum, it also protects against UVA rays, which penetrate deeper into the skin and contribute to premature aging, hyperpigmentation, and long-term damage.

This level of SPF is recommended for most skin types, including those with moderate sun sensitivity. For individuals with fair or very sensitive skin, or under intense sun exposure, a higher SPF of 50+ is advised.

For optimal protection, choose products labeled broad-spectrum to ensure defense against both UVA rays, which contribute to skin aging and pigmentation, and UVB rays that cause sunburn.

It's important to apply sunscreen generously and reapply every two hours or after swimming or sweating to maintain effectiveness.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of iS Clinical Extreme Protect SPF 40

 
Here’s an overview of the pros and cons of iS Clinical Extreme Protect SPF 40 to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Perfect for moisturizing normal skin
  • Balanced texture, neither too light nor too heavy
  • Offers modest anti-wrinkle efficacy
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
  • Provides high sun protection, ideal for prolonged outdoor activities such as hiking or beach outings, and suitable for most skin types

Cons: 

  • We couldn't find any

Ingredients

Est. % Ingredient Origin Functions
60
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
C12-15 Alkyl Benzoate
Function:
Origin:
Glycerin
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Tocopherol
Function:
Origin:
Sorbitan Stearate
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Polyhydroxystearic Acid
Function:
Origin:
Tribehenin
Function:
Origin:
Polyurethane-62
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Polyglyceryl-4 Isostearate
Function:
Origin:
Hexyl Laurate
Function:
Origin:
Cetyl PEG/PPG-10/1 Dimethicone
Function:
Origin:
Butylene Glycol
Function:
Origin:
Xanthan Gum
Function:
Origin:
Aluminum Stearate
Function:
Origin:
Panthenyl Triacetate
Function:
Origin:
Propylene Glycol
Function:
Origin:
Ethyl Linoleate
Function:
Origin:
Asiaticoside
Function:
Origin:
Asiatic Acid
Function:
Origin:
Madecassic Acid
Function:
Origin:
Alumina
Function:
Origin:
Olea Europaea (Olive) Leaf Extract
Function:
Origin:
Sorbitol/Sebacic Acid Copolymer Behenate
Function:
Origin:
Magnesium Aluminum Silicate
Function:
Origin:
Trideceth-6
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Oleyl Alcohol
Function:
Origin:
Aloe Barbadensis Leaf Juice
Function:
Origin:
Isostearic Acid
Function:
Origin:
Disodium EDTA
Function:
Origin:
Polyquaternium-7
Function:
Origin:
Iron Oxides (CI 77499)
Function:
Origin:

Ratings

All humectants
9.2
6
2
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
8.6
4.0
3.0
1.3
0.3
Benchmark
20
Moisturizing rating
6.8
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 9.2 10
9.2
6
2
0.3
0.3
0.3
0.3
Occlusivity All occlusives 8.6 20
4.3
4.0
3.0
1.3
0.3
Moisturizing rating
6.8
Ingredient Est. % Benchmark Humectancy
6
2
0.3
0.3
0.3
0.3
All humectants 9.2 10
9.2
All humectants
9.2
6
2
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
4
3
1.3
0.3
All occlusives 8.6 20
4.3
All occlusives
8.6
4.0
3.0
1.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
3 /10 0.1 0.3 3
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
3
Asiaticoside
3
Ingredient anti-wrinkle power
3 /10
when present at, %
0.1
in this formula, est. %
0.3
Asiatic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Madecassic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Olea Europaea (Olive) Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
3
0.3
0.3
0.3
All antioxidants 3.9 3 Rich in antioxidants
All antioxidants
3.9
Tocopherol
3
Asiaticoside
0.3
Olea Europaea (Olive) Leaf Extract
0.3
Aloe Barbadensis Leaf Juice
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
All soothing 0.3 5 No
All soothing
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %60
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
C12-15 Alkyl Benzoate
Est. %9
Function
Origin
C12-15 Alkyl BenzoateA synthetic emollient ester. It works to improve the appearance of the skin by filling in the microcracks on the surface, thereby making the skin appear softer and smoother. It imparts a lightweight, velvety feel.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Caprylic/Capric Triglyceride
Est. %4
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Tocopherol
Est. %3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Sorbitan Stearate
Est. %2.5
Function
Origin
Sorbitan StearateA vegetable-derived ingredient most commonly used as an emulsifier to stabilize water and oil mixtures.
Pentylene Glycol
Est. %2
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Polyhydroxystearic Acid
Est. %1.5
Function
Origin
Polyhydroxystearic AcidA soft and malleable amber wax naturally derived from vegetable sources. It allows minerals to be very finely dispersed, which can improve SPF, decrease the white cast in sunscreens, and increase the color expression in pigmented products.
Tribehenin
Est. %1.3
Function
Origin
TribeheninA soft, pliable wax that serves as an occlusive moisturizer and emollient. It improves the spreadability of skincare products, including the increased payoff of stick products, and imparts a pleasant, smooth feel upon application.
Polyurethane-62
Est. %1
Function
Origin
Polyurethane-62
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Polyglyceryl-4 Isostearate
Est. %0.3
Function
Origin
Polyglyceryl-4 IsostearateA synthetic emollient emulsifier that helps oil and water phases to mix.
Hexyl Laurate
Est. %0.3
Function
Origin
Hexyl LaurateAn emollient ester with very high spreadability.
Cetyl PEG/PPG-10/1 Dimethicone
Est. %0.3
Function
Origin
Cetyl PEG/PPG-10/1 DimethiconeA silicone-based powerful emulsifier that helps to create lightweight and pleasant feeling lotions and creams.
Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Aluminum Stearate
Est. %0.3
Function
Origin
Aluminum StearateA water-resistant thickener and common ingredient in makeup to help coat the colors used.
Panthenyl Triacetate
Est. %0.3
Function
Origin
Panthenyl Triacetate
Propylene Glycol
Est. %0.3
Function
Origin
Propylene GlycolA clear, thick, odorless liquid of synthetic origin. Its main function is to stabilize cosmetic products exposed to varying temperatures. It is also a moderately strong humectant with similar properties to glycerin.
Ethyl Linoleate
Est. %0.3
Function
Origin
Ethyl Linoleate
Asiaticoside
Est. %0.3
Function
Origin
Asiaticoside

A Gotu Kola or Centella Asiatica derivative with confirmed anti-wrinkle efficacy.

Asiatic Acid
Est. %0.3
Function
Origin
Asiatic AcidA compound isolated from Gotu Kola, a promising anti-wrinkle medicinal plant from Southeast Asia. It is claimed to increase the production of collagen and help with the wound healing process.
Madecassic Acid
Est. %0.3
Function
Origin
Madecassic AcidAn isolated bioactive compound from Gotu Kola. It increases collagen and hyaluronic acid production in the skin and helps to treat wounds, scars, and burns.
Alumina
Est. %0.3
Function
Origin
AluminaA mineral derived from the metal ore known as aluminum. It is commonly used as an abrasive and also acts as a thickening viscosity controlling agent (and thus as a bulking agent). Alumina is also a great opacifier.
Olea Europaea (Olive) Leaf Extract
Est. %0.3
Function
Origin
Olea Europaea (Olive) Leaf ExtractAn antioxidant and fragrant extract from the leaves of the olive tree. It contains a promising anti-aging compound called Oleuropein, and a prospective anti-pigment compound called Cornoside.
Sorbitol/Sebacic Acid Copolymer Behenate
Est. %0.3
Function
Origin
Sorbitol/Sebacic Acid Copolymer Behenate
Magnesium Aluminum Silicate
Est. %0.3
Function
Origin
Magnesium Aluminum SilicateA naturally occurring clay that is hygroscopic, which means that it easily absorbs water. This ingredient is thus commonly used as an absorbent and emulsion stabilizer. It also modifies slip by improving the spreadability of the products it is used in.
Trideceth-6
Est. %0.3
Function
Origin
Trideceth-6
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Oleyl Alcohol
Est. %0.3
Function
Origin
Oleyl Alcohol
Aloe Barbadensis Leaf Juice
Est. %0.3
Function
Origin
Aloe Barbadensis Leaf JuiceA gelatinous juice from Aloe vera leaves that acts as a powerful humectant, emollient, and antioxidant. It contains enzymes, amino acids, vitamins, and minerals that soothe irritated skin and have wound-healing and anti-inflammatory properties.
Isostearic Acid
Est. %0.3
Function
Origin
Isostearic AcidA saturated fatty acid used to mix oil and water and to remove dirt from the skin's surface. Isostearic acid is listed among common comedogenic ingredients by acne.org.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Polyquaternium-7
Est. %0.3
Function
Origin
Polyquaternium-7A positively-charged ingredient that forms films to protect the rest of the product.
Iron Oxides (CI 77499)
Est. %0.3
Function
Origin
Iron Oxides (CI 77499)A black colorant also known as black iron oxide used in a wide range of skincare products.