Renewcell Retinol 2% + Argireline Review

Renewcell Retinol 2% + Argireline
1.3
/ 10
Moisturizing
2.4 Humectancy icon Humectancy
0.3 Occlusivity icon Occlusivity
10Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

Renewcell Retinol 2% + Argireline Ingredients

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Full Ingredient List (INCI):

Water, Retinol, Hyaluronic Acid, 3-O-Ethyl Ascorbic Acid, Niacinamide, 4-Butylresorcinol, Tocopheryl Acetate, Collagen, Alpha-Arbutin, Glutathione, Camellia Sinensis Leaf Extract, Dipotassium Glycyrrhizate, Bisabolol, Argania Spinosa Kernel Oil, Bakuchiol, Acetyl Hexapeptide-8, Hexapeptide-2, Zinc Oxide, Titanium Dioxide (CI 77891), Hydrogenated Ethylhexyl Olivate, Hydrogenated Olive Oil, Xanthan Gum, Lecithin, Sclerotium Gum, Sodium Gluconate, Ethylhexylglycerin
Review

Does Renewcell Retinol 2% + Argireline Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Renewcell Retinol 2% + Argireline has to offer:
 
✅ A bit of moisturizing. It has a moisturizing rating of 1.3 out of 10.
✅ Potent anti-wrinkle effect with the highest possible efficacy rating. With an anti-wrinkle rating of 10 out of 10, Renewcell Retinol 2% + Argireline is highly potent in reducing wrinkles.
✅ Antioxidant protection

  

Key Benefits of Renewcell Retinol 2% + Argireline

 
These are the key benefits you can expect from using Renewcell Retinol 2% + Argireline:
 

🔵 Slight Moisturizing When Used Alone

According to CreamScan analysis, Renewcell Retinol 2% + Argireline is slightly moisturizing, with a moisturizing rating of 1.3 out of 10.

Is it more humectant or occlusive? This product has relatively comparable levels of Humectancy and Occlusivity: a low Humectancy of 2.4 out of 10 and a low Occlusivity of 0.3 out of 10.

This type of product provides relatively light moisturizing on its own but can contribute to overall moisturizing efficacy when used as part of a skincare routine, alongside another moisturizer.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣🟣 Potent Anti-Wrinkle Efficacy

According to CreamScan analysis, Renewcell Retinol 2% + Argireline has a maximum anti-wrinkle rating of 10 out of 10.

It contains 2 active ingredients with proven anti-wrinkle efficacy:

1️⃣ Retinol (est. ≈2.0%),
 the most effective non-prescription anti-wrinkle ingredient. Numerous clinical studies have shown its positive effects at concentrations as low as 0.1%. A study with 36 participants (Kafi et al.) confirmed that a lotion containing 0.4% retinol reduced wrinkle severity by 21% after 24 weeks of use, compared to the same formulation without retinol (vehicle).
 
2️⃣ Niacinamide (est. ≈0.3%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Renewcell Retinol 2% + Argireline contains some ingredients often marketed as effective in reducing wrinkles, specifically 3-O-Ethyl Ascorbic Acid, Camellia Sinensis Leaf Extract, Bakuchiol, and Acetyl Hexapeptide-8. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Renewcell Retinol 2% + Argireline is rich (> 3%) in antioxidants, specifically Hyaluronic Acid (est. ≈0.3%), 3-O-Ethyl Ascorbic Acid (est. ≈0.3%), Niacinamide (est. ≈0.3%), and others.

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Renewcell Retinol 2% + Argireline

 
CreamScan identified a few things to consider before adding Renewcell Retinol 2% + Argireline to your skincare routine:
 

⚠️ May Increase Skin Photosensitivity Due to Retinol

This product contains retinol, which offers powerful anti-wrinkle benefits. The mechanism behind retinol’s action is boosting cell turnover. This process exposes new, more delicate skin, making it more vulnerable to sun damage.

As a result, using products with retinol may increase the skin's sensitivity, making it more prone to sunburn or irritation when exposed to UV rays.

To protect the skin, dermatologists recommend applying a broad-spectrum sunscreen with at least SPF 30 throughout the duration of retinol treatment, along with avoiding direct sun exposure. Retinol should be used at night, as it is sensitive to sunlight and can lose its potency when exposed to UV rays.

📌 Please always check the manufacturer's instructions for using the retinol-containing products, either on their website or product label.

⚠️ As a Standalone Moisturizer, It Has Relatively Low Moisturizing Potential

If you use Renewcell Retinol 2% + Argireline for moisturizing purposes, please keep in mind that it provides relatively light moisturizing on its own, and, more importantly, it’s not optimal for any skin type.

On one hand, it has low occlusivity, which suits oily and combination skin. On the other hand, it has a low estimated concentration of humectants, which are essential for effective moisturizing of all skin types, including oily skin.

Therefore, if used as a standalone moisturizer, this product should be paired with a humectant-rich moisturizer for optimal skin hydration.

Pros & Cons of Renewcell Retinol 2% + Argireline

 
Here’s an overview of the pros and cons of Renewcell Retinol 2% + Argireline to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

Provides relatively light moisturizing on its own but can contribute to the moisturizing efficacy of any skincare routine
Delivers potent anti-wrinkle efficacy with the highest possible rating of 10 out of 10 thanks to Retinol and Niacinamide
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

⚠️ May increase skin photosensitivity due to retinol
⚠️ Minimal moisturizing efficacy, even for oily skin - something to keep in mind if this is the only moisturizer in your routine
   

Summary: Renewcell Retinol 2% + Argireline

 
Based on the ingredient list analysis, CreamScan AI suggests that Renewcell Retinol 2% + Argireline
 is highly effective in treating wrinkles, featuring ingredients with solid, robust evidence of anti-wrinkle efficacy, in concentrations that may deliver a significant anti-wrinkle effect.
 

As a moisturizer, it provides relatively light hydration on its own but can enhance the moisturizing efficacy of any skincare routine.

With its high antioxidant content, Renewcell Retinol 2% + Argireline helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about Renewcell Retinol 2% + Argireline worth noting.
 
If you use Renewcell Retinol 2% + Argireline as your primary moisturizer, please keep in mind that it provides only light hydration, which isn’t actually ideal for any skin type. While its low occlusivity may work for oily and combination skin, it lacks sufficient humectants, which are vital for effective hydration of any skin type. Therefore, for optimal moisturizing results, it should be paired with a humectant-rich moisturizer.
 
This product contains retinol, the most powerful and well-researched non-prescription anti-wrinkle ingredient. However, retinol can make your skin more prone to sun damage and increase sensitivity, so it’s recommended to use a broad-spectrum sunscreen with at least SPF 30 throughout the duration of retinol treatment.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
90
2
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Retinol
Function:
Origin:
Hyaluronic Acid
Function:
Origin:
3-O-Ethyl Ascorbic Acid
Function:
Origin:
Niacinamide
Function:
Origin:
4-Butylresorcinol
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Collagen
Function:
Origin:
Alpha-Arbutin
Function:
Origin:
Glutathione
Function:
Origin:
Camellia Sinensis Leaf Extract
Function:
Origin:
Dipotassium Glycyrrhizate
Function:
Origin:
Bisabolol
Function:
Origin:
Argania Spinosa Kernel Oil
Function:
Origin:
Bakuchiol
Function:
Origin:
Acetyl Hexapeptide-8
Function:
Origin:
Hexapeptide-2
Function:
Origin:
Zinc Oxide
Function:
Origin:
Titanium Dioxide (CI 77891)
Function:
Origin:
Hydrogenated Ethylhexyl Olivate
Function:
Origin:
Hydrogenated Olive Oil
Function:
Origin:
Xanthan Gum
Function:
Origin:
Lecithin
Function:
Origin:
Sclerotium Gum
Function:
Origin:
Sodium Gluconate
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:

Ratings

All humectants
2.4
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.6
0.3
0.3
Benchmark
20
Moisturizing rating
1.3
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 2.4 10
2.4
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.6 20
0.3
0.3
0.3
Moisturizing rating
1.3
Ingredient Est. % Benchmark Humectancy
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 2.4 10
2.4
All humectants
2.4
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
All occlusives 0.6 20
0.3
All occlusives
0.6
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
10 /10 0.4 2 10
6 /10 4 0.3 0.4
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
10
Retinol
10
Ingredient anti-wrinkle power
10 /10
when present at, %
0.4
in this formula, est. %
2
Niacinamide
0.4
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
0.3
3-O-Ethyl Ascorbic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Camellia Sinensis Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Bakuchiol
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Hexapeptide-8
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
10
Ingredient Est. % Benchmark
Rich in Antioxidants
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 3 3 Rich in antioxidants
All antioxidants
3
Niacinamide
0.3
Hyaluronic Acid
0.3
3-O-Ethyl Ascorbic Acid
0.3
4-Butylresorcinol
0.3
Tocopheryl Acetate
0.3
Alpha-Arbutin
0.3
Glutathione
0.3
Camellia Sinensis Leaf Extract
0.3
Argania Spinosa Kernel Oil
0.3
Bakuchiol
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
0.3
All soothing 1.2 5 No
All soothing
1.2
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %90
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Retinol
Est. %2
Function
Origin
Retinol

One of the most famous and well-researched anti-aging ingredients with a maximum anti-wrinkle power of 10 out of 10. It is proven to decrease wrinkles and help the skin regain its thickness, firmness, and texture. Retinol is also effective in treating pigmentation issues such as dark spots and acne.

Hyaluronic Acid
Est. %0.3
Function
Origin
Hyaluronic Acid

A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.

3-O-Ethyl Ascorbic Acid
Est. %0.3
Function
Origin
3-O-Ethyl Ascorbic AcidA derivative of vitamin C. Its stability in skincare formulations is better than ascorbic acid’s, although clinical studies are yet to indicate whether it has the same collagen-boosting benefits.
Niacinamide
Est. %0.3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

4-Butylresorcinol
Est. %0.3
Function
Origin
4-Butylresorcinol
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Collagen
Est. %0.3
Function
Origin
CollagenA protein that builds all human tissues, especially skin and joints. It is used as a moisturizing humectant ingredient in skincare.
Alpha-Arbutin
Est. %0.3
Function
Origin
Alpha-Arbutin
Glutathione
Est. %0.3
Function
Origin
GlutathioneA naturally occurring tripeptide that combats free radicals and acts as a reducing agent.
Camellia Sinensis Leaf Extract
Est. %0.3
Function
Origin
Camellia Sinensis Leaf Extract

An antioxidant green tea extract. In the deeper layers, it slows down the destruction of collagen, elastin, and hyaluronic acid – thus delaying the signs of aging. It also acts as an anti-acne, soothing, moisturizing, and emollient ingredient.

Dipotassium Glycyrrhizate
Est. %0.3
Function
Origin
Dipotassium GlycyrrhizateA licorice root derivative with powerful anti-inflammatory and soothing activities. It is often used as a flavoring agent in lip products.
Bisabolol
Est. %0.3
Function
Origin
Bisabolol

An anti-inflammatory compound found naturally in German chamomile essential oil. It has a pleasant, sweet, and floral scent. Bisabolol also has soothing and anti-inflammatory properties but can cause an allergic reaction in more sensitive individuals.

Argania Spinosa Kernel Oil
Est. %0.3
Function
Origin
Argania Spinosa Kernel OilA fatty oil from Moroccan argan tree kernels commonly used as an occlusive moisturizer and emollient. Its uniqueness comes from its compounds: vitamin E, phospholipids, phenolic compounds, and rare phytosterols with antioxidant and emollient effects.
Bakuchiol
Est. %0.3
Function
Origin
BakuchiolA newly discovered bioactive obtained from the seeds of Babchi. It boosts collagen production like retinol, but with fewer side effects. Its effects include reduced wrinkles and faded pigmentation.
Acetyl Hexapeptide-8
Est. %0.3
Function
Origin
Acetyl Hexapeptide-8

A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way.

Hexapeptide-2
Est. %0.3
Function
Origin
Hexapeptide-2
Zinc Oxide
Est. %0.3
Function
Origin
Zinc OxideA white mineral powder mainly used in skincare as a physical sunscreen. It protects against UVA light that leads to visible signs of aging, including wrinkles and fine lines. Zinc oxide can also be used as a colorant to enhance the whiteness of a product.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
Titanium Dioxide (CI 77891)One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.
Hydrogenated Ethylhexyl Olivate
Est. %0.3
Function
Origin
Hydrogenated Ethylhexyl Olivate
Hydrogenated Olive Oil
Est. %0.3
Function
Origin
Hydrogenated Olive OilA transformed olive oil that is rich in occlusive moisturizing oleic and linoleic fatty acids. It also helps to thicken a formula.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Lecithin
Est. %0.3
Function
Origin
LecithinA humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Sclerotium Gum
Est. %0.3
Function
Origin
Sclerotium GumA thickener with a silky, velvety feel that many manufacturers use as an alternative to silicones.
Sodium Gluconate
Est. %0.3
Function
Origin
Sodium GluconateA chelating ingredient that ensures that the harmful metal ions in a formula are unreactive. It also protects other ingredients from degrading.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.