One Thing Niacinamide Glutathione Serum

One Thing Niacinamide Glutathione Serum
5.5
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
1.0 Occlusivity icon Occlusivity
6.1Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers

Review

Does One Thing Niacinamide Glutathione Serum work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using One Thing Niacinamide Glutathione Serum:

  • Moderate moisturizing. It has a moisturizing rating of 5.5 out of 10.
  • Significant anti-wrinkle efficacy. With an anti-wrinkle rating of 6.1 out of 10, One Thing Niacinamide Glutathione Serum is effective in minimizing wrinkles.
  • Soothing: One Thing Niacinamide Glutathione Serum contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
  • Antioxidant protection.

How moisturizing is it?

Quite moisturizing: One Thing Niacinamide Glutathione Serum has a moisturizing rating of 5.5 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 1.0 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Niacinamide (est. ≈5.0%), Butylene Glycol (est. ≈4.0%) and Glycerin (est. ≈3.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, One Thing Niacinamide Glutathione Serum has a high anti-wrinkle rating of 6.1 out of 10.

It contains 2 active ingredients with proven anti-wrinkle efficacy:

  • Niacinamide (est. ≈5.0%),
     one of the most effective and well-researched anti-wrinkle ingredients.
  • Ascorbic Acid (est. ≈0.3%),
     or Vitamin C, a popular anti-wrinkle ingredient, yet with average efficacy confirmed by only one study.
Among others, One Thing Niacinamide Glutathione Serum also contains contains 3-O-Ethyl Ascorbic Acid and Sodium Ascorbate, two ingredients marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Antioxidant benefits

We estimate that One Thing Niacinamide Glutathione Serum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈5.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Skin soothing

Based on the ingredient list analysis, One Thing Niacinamide Glutathione Serum is rich (> 5%) in soothing ingredients, particularly Niacinamide (est. ≈5.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

Ingredients

Est. % Ingredient Origin Functions
75
5
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Niacinamide
Function:
Origin:
Butylene Glycol
Function:
Origin:
Glycerin
Function:
Origin:
Propanediol
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Hydroxyacetophenone
Function:
Origin:
Glycereth-25 PCA Isostearate
Function:
Origin:
Coptis Chinensis Rhizome Extract
Function:
Origin:
Citric Acid
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Citrus Unshiu Peel Extract
Function:
Origin:
Xanthan Gum
Function:
Origin:
Zea Mays (Corn) Germ Extract
Function:
Origin:
Disodium EDTA
Function:
Origin:
Glutathione
Function:
Origin:
Hyaluronic Acid
Function:
Origin:
Hydrolyzed Hyaluronic Acid
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Fructan
Function:
Origin:
Melaleuca Alternifolia (Tea Tree) Leaf Extract
Function:
Origin:
Glucose
Function:
Origin:
3-O-Ethyl Ascorbic Acid
Function:
Origin:
Ascorbic Acid
Function:
Origin:
Sodium Ascorbate
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Linoleic Acid
Function:
Origin:
Tocopherol
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Oil
Function:
Origin:
Oleic Acid
Function:
Origin:
Palmitic Acid
Function:
Origin:
Stearic Acid
Function:
Origin:
Linolenic Acid
Function:
Origin:

Ratings

All humectants
15.8
5
4
3
2
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
2.1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.5
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 15.8 10
10.0
5
4
3
2
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 2.1 20
1.0
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Moisturizing rating
5.5
Ingredient Est. % Benchmark Humectancy
5
4
3
2
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 15.8 10
10
All humectants
15.8
5
4
3
2
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All occlusives 2.1 20
1.0
All occlusives
2.1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 5 6
2.5 /10 5 0.3 0.1
n/a
- 0.3 -
n/a
- 0.3 -
Total
6.1
Niacinamide
6
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
5
Ascorbic Acid
0.1
Ingredient anti-wrinkle power
2.5 /10
when present at, %
5
in this formula, est. %
0.3
3-O-Ethyl Ascorbic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Sodium Ascorbate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
6.1
Ingredient Est. % Benchmark
Rich in Antioxidants
5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 9.3 3 Rich in antioxidants
All antioxidants
9.3
Niacinamide
5
Hydroxyacetophenone
1.3
Ascorbic Acid
0.3
Citrus Unshiu Peel Extract
0.3
Glutathione
0.3
Hyaluronic Acid
0.3
Hydrolyzed Hyaluronic Acid
0.3
Sodium Hyaluronate
0.3
3-O-Ethyl Ascorbic Acid
0.3
Sodium Ascorbate
0.3
Tocopheryl Acetate
0.3
Tocopherol
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
5
All soothing 5 5 Rich in soothing
All soothing
5
5
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Niacinamide
Est. %5
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Butylene Glycol
Est. %4
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Propanediol
Est. %2
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
1,2-Hexanediol
Est. %1.5
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Hydroxyacetophenone
Est. %1.3
Function
Origin
HydroxyacetophenoneAn antioxidant compound that can be found in many plants, although it is manufactured synthetically for skincare purposes. It can boost the preservative action of other conservants.
Glycereth-25 PCA Isostearate
Est. %1
Function
Origin
Glycereth-25 PCA Isostearate
Coptis Chinensis Rhizome Extract
Est. %0.3
Function
Origin
Coptis Chinensis Rhizome Extract
Citric Acid
Est. %0.3
Function
Origin
Citric AcidA gently exfoliating AHA that helps to remove the top layer of dead skin cells. In comparison to other AHAs, citric acid has been shown to be one of the least effective. It is also very commonly used as a stabilizing and pH-controlling agent.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Citrus Unshiu Peel Extract
Est. %0.3
Function
Origin
Citrus Unshiu Peel ExtractThis extract derived from satsuma mandarins mainly contains a fragrant essential oil. It is rich in antioxidant flavonoids, organic acids, and limonoids – promising anti-pigment and anti-wrinkle compounds.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Zea Mays (Corn) Germ Extract
Est. %0.3
Function
Origin
Zea Mays (Corn) Germ Extract
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Glutathione
Est. %0.3
Function
Origin
GlutathioneA naturally occurring tripeptide that combats free radicals and acts as a reducing agent.
Hyaluronic Acid
Est. %0.3
Function
Origin
Hyaluronic Acid

A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.

Hydrolyzed Hyaluronic Acid
Est. %0.3
Function
Origin
Hydrolyzed Hyaluronic AcidA smaller-molecule version of the regular hyaluronic acid. It is a powerful humectant that absorbs into the skin and offers moisturizing, smoothing, and anti-wrinkle effects. It is also slightly anti-inflammatory and displays subtle antioxidant properties.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Fructan
Est. %0.3
Function
Origin
Fructan
Melaleuca Alternifolia (Tea Tree) Leaf Extract
Est. %0.3
Function
Origin
Melaleuca Alternifolia (Tea Tree) Leaf ExtractA fragrant tea tree leaf extract with antimicrobial, antiseptic, and antioxidant flavonoids and terpenoids.
Glucose
Est. %0.3
Function
Origin
GlucoseA simple sugar that is also one of two components of sucrose, or table sugar. It is used as a humectant in skincare products. Glucose is also used to flavor lip care cosmetics because of its mildly sweet taste.
3-O-Ethyl Ascorbic Acid
Est. %0.3
Function
Origin
3-O-Ethyl Ascorbic AcidA derivative of vitamin C. Its stability in skincare formulations is better than ascorbic acid’s, although clinical studies are yet to indicate whether it has the same collagen-boosting benefits.
Ascorbic Acid
Est. %0.3
Function
Origin
Ascorbic Acid

Also known as vitamin C, this multi-benefit ingredient has proven anti-wrinkle, antioxidant, and anti-pigmentation efficacy. It degrades easily when exposed to air and light, so it requires proper packaging to maintain its stability.

Sodium Ascorbate
Est. %0.3
Function
Origin
Sodium AscorbateA well-researched sodium salt of vitamin C. It has antioxidant, collagen-boosting, and pigment-improving properties. It degrades very easily when exposed to air and needs careful packaging.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Linoleic Acid
Est. %0.3
Function
Origin
Linoleic AcidA fatty acid isolated from various plant oils (notably evening primrose, safflower, grape seed, and sunflower oil). It is an occlusive moisturizer and emollient that doesn't leave an oily, sticky residue and is especially suitable for oily and acne-prone skin.
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Helianthus Annuus (Sunflower) Seed Oil
Est. %0.3
Function
Origin
Helianthus Annuus (Sunflower) Seed OilA fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Oleic Acid
Est. %0.3
Function
Origin
Oleic AcidAn omega-9 fatty acid commonly found in vegetable oils. It is occlusive moisturizing, emollient and emulsifying.
Palmitic Acid
Est. %0.3
Function
Origin
Palmitic AcidA saturated fatty acid used in skincare as a strongly occlusive moisturizer and barrier repairing, emollient ingredient. It is a waxy-looking, white solid. Palmitic acid can be commonly found in animal and vegetable fats, notably palm oil.
Stearic Acid
Est. %0.3
Function
Origin
Stearic AcidA saturated fatty acid found in vegetable butter and animal fats. It is an occlusive moisturizing and emollient ingredient and also helps to maintain the barrier function of the skin.
Linolenic Acid
Est. %0.3
Function
Origin
Linolenic AcidAn essential polyunsaturated occlusive fatty acid isolated from various plant oils. It is necessary for the correct barrier function of the skin and moisturizes without leaving a sticky after-feel.