NIOD Copper Amino Isolate Serum 3 1:1 (CAIS3)

NIOD Copper Amino Isolate Serum 3 1:1 (CAIS3)
4.0
/ 10
Moisturizing
8.1 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity

Review

Does NIOD Copper Amino Isolate Serum 3 1:1 (CAIS3) work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using NIOD Copper Amino Isolate Serum 3 1:1 (CAIS3):

  • Moderate moisturizing. It has a moisturizing rating of 4.0 out of 10.

Lightweight moisturizer ideal for oily skin and a humectant boost for any skincare routine

According to CreamScan analysis, NIOD Copper Amino Isolate Serum 3 1:1 (CAIS3) is quite moisturizing, with a moisturizing rating of 4.0 out of 10.

Is it more humectant or occlusive? Purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a very high humectancy of 8.1 out of 10, primarily due to the high content of Glycerin (est. ≈6.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

Tip: Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Questionable anti-wrinkle efficacy

According to CreamScan analysis, NIOD Copper Amino Isolate Serum 3 1:1 (CAIS3) has a zero anti-wrinkle rating.

It contains Trifluoroacetyl Tripeptide-2, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Trifluoroacetyl Tripeptide-2 provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards. Therefore, this ingredient does not generate the anti-wrinkle rating.

Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Ingredients

Est. % Ingredient Origin Functions
80
6
4
3
2
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Glycerin
Function:
Origin:
Tripeptide-29
Function:
Origin:
Bis(Tripeptide-1) Copper Acetate
Function:
Origin:
Acetyl Tripeptide-1
Function:
Origin:
Myristoyl Nonapeptide-3
Function:
Origin:
Trifluoroacetyl Tripeptide-2
Function:
Origin:
Acetyl Tetrapeptide-2
Function:
Origin:
Sodium Hyaluronate Crosspolymer
Function:
Origin:
Glycogen
Function:
Origin:
Propanediol
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Dextran
Function:
Origin:
Dimethyl Isosorbide
Function:
Origin:
Ethoxydiglycol
Function:
Origin:
Isoceteth-20
Function:
Origin:
Leuconostoc/Radish Root Ferment Filtrate
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Chlorphenesin
Function:
Origin:

Ratings

All humectants
8.1
6
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
4.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 8.1 10
8.1
6
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
4.0
Ingredient Est. % Benchmark Humectancy
6
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 8.1 10
8.1
All humectants
8.1
6
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 0.3 -
Total
0
Trifluoroacetyl Tripeptide-2
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
None
All antioxidants 0 3 No
All antioxidants
0
None
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
None
All soothing 0 5 No
All soothing
0
None
Benchmark
5

Ingredients explained

Water
Est. %80
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Tripeptide-29
Est. %4
Function
Origin
Tripeptide-29
Bis(Tripeptide-1) Copper Acetate
Est. %3
Function
Origin
Bis(Tripeptide-1) Copper Acetate
Acetyl Tripeptide-1
Est. %2
Function
Origin
Acetyl Tripeptide-1
Myristoyl Nonapeptide-3
Est. %0.3
Function
Origin
Myristoyl Nonapeptide-3

Description is coming soon

Trifluoroacetyl Tripeptide-2
Est. %0.3
Function
Origin
Trifluoroacetyl Tripeptide-2

A synthetically made peptide that was shown to slow down the degradation of elastin in the skin. It is said to be able to reduce sagging and wrinkles in different parts of the face, although this has not been well researched yet.

Acetyl Tetrapeptide-2
Est. %0.3
Function
Origin
Acetyl Tetrapeptide-2

Description is coming soon

Sodium Hyaluronate Crosspolymer
Est. %0.3
Function
Origin
Sodium Hyaluronate CrosspolymerA modified version of regular hyaluronic acid. It attracts large volumes of water, thereby making it an effective humectant moisturizing ingredient.
Glycogen
Est. %0.3
Function
Origin
GlycogenGlycogen is a substance that is used in the body to store and release sugar as a form of energy storage. In skincare, however, it is utilized as a humectant moisturizing ingredient due to the thousands of glucose units in its molecule. These glucose chains attract and bind water, leaving the skin moisturized.
Propanediol
Est. %0.3
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Pentylene Glycol
Est. %0.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Dextran
Est. %0.3
Function
Origin
DextranA naturally derived sucrose metabolite that thickens water and bulks emulsions.
Dimethyl Isosorbide
Est. %0.3
Function
Origin
Dimethyl IsosorbideA solvent for active ingredients that is claimed to help them better penetrate the outer layer of skin. It also helps to reduce the thickness of a product.
Ethoxydiglycol
Est. %0.3
Function
Origin
EthoxydiglycolA type of alcohol with humectant moisturizing properties. It also acts as a solvent, since it mixes well with a variety of other compounds, including water and even some oils.
Isoceteth-20
Est. %0.3
Function
Origin
Isoceteth-20A synthetically produced emulsifier and surfactant. It can create foam for mild cleansing or help stabilize oil-in-water emulsions.
Leuconostoc/Radish Root Ferment Filtrate
Est. %0.3
Function
Origin
Leuconostoc/Radish Root Ferment FiltrateA biotechnological fermentation ingredient that is created by feeding radish root to Leuconostoc kimchii. It allegedly contains organic acids and a mixture of peptides known as bacteriocins – which have antimicrobial activity.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Chlorphenesin
Est. %0.3
Function
Origin
ChlorphenesinA preservative and broad-spectrum antimicrobial agent that protects products from a wide range of bacteria and fungi.