Neocutis Hyalis+ Hydrating Serum Review

Neocutis Hyalis+ Hydrating Serum
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
Rich
in Antioxidants
Ingredients

Neocutis Hyalis+ Hydrating Serum Ingredients

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Full Ingredient List (INCI):

Water, Sorbitol, Acetyl Glucosamine, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Polyglutamic Acid, Caprylyl Glycol, Pentylene Glycol, Phenoxyethanol
Review

Does Neocutis Hyalis+ Hydrating Serum Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Neocutis Hyalis+ Hydrating Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
✅ Antioxidant protection

  

Key Benefits of Neocutis Hyalis+ Hydrating Serum

 
These are the key benefits you can expect from using Neocutis Hyalis+ Hydrating Serum:
 

🔵 Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, Neocutis Hyalis+ Hydrating Serum is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Sorbitol (est. ≈6.0%), Sodium Hyaluronate (est. ≈2.5%) and Hydrolyzed Sodium Hyaluronate (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Neocutis Hyalis+ Hydrating Serum is rich (> 3%) in antioxidants, specifically Sodium Hyaluronate (est. ≈2.5%) and Hydrolyzed Sodium Hyaluronate (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Neocutis Hyalis+ Hydrating Serum

 
CreamScan identified a few things to consider before adding Neocutis Hyalis+ Hydrating Serum to your skincare routine:
 

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using Neocutis Hyalis+ Hydrating Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

⚠️ Questionable anti-wrinkle efficacy

If one of your main reasons for choosing Neocutis Hyalis+ Hydrating Serum is its potential anti-aging effects, please note that, according to CreamScan analysis, it currently has a zero anti-wrinkle rating.

It contains Acetyl Glucosamine, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Acetyl Glucosamine provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards.

While this does not categorically rule out the possibility that Acetyl Glucosamine may reduce wrinkles, its efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.

Therefore, this ingredient does not generate the anti-wrinkle rating.

📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Pros & Cons of Neocutis Hyalis+ Hydrating Serum

 
Here’s an overview of the pros and cons of Neocutis Hyalis+ Hydrating Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants
⚠️ Questionable anti-wrinkle efficacy
   

Summary: Neocutis Hyalis+ Hydrating Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Neocutis Hyalis+ Hydrating Serum
, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
With its high antioxidant content, Neocutis Hyalis+ Hydrating Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about Neocutis Hyalis+ Hydrating Serum worth noting.
 
Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.
 
If one of your main reasons for considering Neocutis Hyalis+ Hydrating Serum is its potential anti-aging effects, please note that, according to CreamScan analysis, its anti-wrinkle efficacy is questionable. None of the ingredients in this product provide substantial evidence of their anti-wrinkle efficacy according to CreamScan Research Evaluation Standards.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
80
6
4
2.5
2
1.5
1.3
1
0.3
0.3
Est. %
Water
Function:
Origin:
Sorbitol
Function:
Origin:
Acetyl Glucosamine
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Hydrolyzed Sodium Hyaluronate
Function:
Origin:
Sodium Hyaluronate Crosspolymer
Function:
Origin:
Polyglutamic Acid
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Phenoxyethanol
Function:
Origin:

Ratings

All humectants
14.6
6
2.5
2
1.5
1.3
1
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 14.6 10
10.0
6
2.5
2
1.5
1.3
1
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
6
2.5
2
1.5
1.3
1
0.3
All humectants 14.6 10
10
All humectants
14.6
6
2.5
2
1.5
1.3
1
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 4 -
Total
0
Acetyl Glucosamine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
4
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
2.5
2
All antioxidants 4.5 3 Rich in antioxidants
All antioxidants
4.5
Sodium Hyaluronate
2.5
Hydrolyzed Sodium Hyaluronate
2
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
None
All soothing 0 5 No
All soothing
0
None
Benchmark
5

Ingredients explained

Water
Est. %80
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Sorbitol
Est. %6
Function
Origin
SorbitolA sweet-tasting alcohol derived from glucose. Aside from its sweet taste (for which it is used as a very common sweetener), Sorbitol is also very good at retaining water and is used in skincare as a humectant.
Acetyl Glucosamine
Est. %4
Function
Origin
Acetyl GlucosamineA body-natural amino-saccharide used in skincare as an anti-pigment ingredient. Some other benefits of acetyl glucosamine include decreased skin flakiness, improved wound healing, and even a slight reduction in facial wrinkles.
Sodium Hyaluronate
Est. %2.5
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Hydrolyzed Sodium Hyaluronate
Est. %2
Function
Origin
Hydrolyzed Sodium HyaluronateA very small-molecule version of regular sodium hyaluronate. It is a powerful humectant skin-identical ingredient that absorbs into the skin and offers plumping, smoothing, and anti-wrinkle effects.
Sodium Hyaluronate Crosspolymer
Est. %1.5
Function
Origin
Sodium Hyaluronate CrosspolymerA modified version of regular hyaluronic acid. It attracts large volumes of water, thereby making it an effective humectant moisturizing ingredient.
Polyglutamic Acid
Est. %1.3
Function
Origin
Polyglutamic AcidA natural polymer with incredible water-binding properties that is prepared from glutamic acid through fermentation.
Caprylyl Glycol
Est. %1
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Pentylene Glycol
Est. %0.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.