iS Clinical Super Serum Advance+ Review

iS Clinical Super Serum Advance+
4.5
/ 10
Moisturizing
9.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
5.5Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Review

Does iS Clinical Super Serum Advance+ Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what iS Clinical Super Serum Advance+ has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 4.5 out of 10.
  • Considerable anti-wrinkle efficacy: iS Clinical Super Serum Advance+ has an anti-wrinkle rating of 5.5 out of 10, indicating a moderate ability to reduce wrinkles.
  • Antioxidant protection.

Key Benefits of iS Clinical Super Serum Advance+

 
These are the key benefits you can expect from using iS Clinical Super Serum Advance+:
 

Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, iS Clinical Super Serum Advance+ is quite moisturizing, with a moisturizing rating of 4.5 out of 10.

Is it more humectant or occlusive? Purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a very high humectancy of 9.0 out of 10, primarily due to the high content of Hyaluronic Acid (est. ≈2.5%), Pentylene Glycol (est. ≈2.4%) and Urea (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

Tip: Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Considerable Anti-Wrinkle Efficacy

According to CreamScan analysis, iS Clinical Super Serum Advance+ has a moderate anti-wrinkle rating of 5.5 out of 10.

It contains 2 active ingredients with proven anti-wrinkle efficacy:

  • Asiaticoside (est. ≈0.3%),
     derived from the plant Centella asiatica, an ingredient with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 27 participants (Lee et al.). This study demonstrated that a cream containing 0.1% asiaticoside reduced the average wrinkle depth by 8% after 12 weeks of use, compared to a vehicle (the same formulation without asiaticoside).
  • Ascorbic Acid (est. ≈6.0%),
     or Vitamin C, a popular ingredient, yet with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 20 participants (Humbert et al.). This study showed that a cream with a relatively high concentration of 5% ascorbic acid reduced the average wrinkle depth by 7% after 6 months of use, compared to a vehicle (the same formulation without ascorbic acid).
Among others, iS Clinical Super Serum Advance+ also contains contains Tripeptide-1 and Asiatic Acid, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that iS Clinical Super Serum Advance+ is rich (> 3%) in antioxidants, specifically Ascorbic Acid (est. ≈6.0%) and Hyaluronic Acid (est. ≈2.5%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: iS Clinical Super Serum Advance+

 
CreamScan AI identified a few things to consider before adding iS Clinical Super Serum Advance+ to your skincare routine:
 

If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using iS Clinical Super Serum Advance+ as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of iS Clinical Super Serum Advance+

 
Here’s an overview of the pros and cons of iS Clinical Super Serum Advance+ to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Humectant-rich moisturizing ideal for oily skin
  • Lightweight texture
  • A humectant moisturizing boost for any skincare routine
  • Provides considerable anti-wrinkle efficacy
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage such as UV radiation and pollution

Cons: 

  • Needs occlusives to seal in humectants if used as a standalone moisturizer

Ingredients

Est. % Ingredient Origin Functions
80
6
2.5
2.4
2
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Ascorbic Acid
Function:
Origin:
Hyaluronic Acid
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Urea
Function:
Origin:
Glucose
Function:
Origin:
Guanidine HCl
Function:
Origin:
Tripeptide-1
Function:
Origin:
Arbutin
Function:
Origin:
Polyporus Umbellatus (Mushroom) Extract
Function:
Origin:
Calcium Pantothenate
Function:
Origin:
Asiaticoside
Function:
Origin:
Asiatic Acid
Function:
Origin:
Zinc Sulfate
Function:
Origin:
Glycerin
Function:
Origin:
Phenoxyethanol
Function:
Origin:

Ratings

All humectants
9.0
2.5
2.4
2
1.5
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
4.5
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 9.0 10
9.0
2.5
2.4
2
1.5
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
4.5
Ingredient Est. % Benchmark Humectancy
2.5
2.4
2
1.5
0.3
0.3
All humectants 9.0 10
9
All humectants
9.0
2.5
2.4
2
1.5
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
3 /10 0.1 0.3 3
2.5 /10 5 6 2.5
n/a
- 0.3 -
n/a
- 0.3 -
Total
5.5
Asiaticoside
3
Ingredient anti-wrinkle power
3 /10
when present at, %
0.1
in this formula, est. %
0.3
Ascorbic Acid
2.5
Ingredient anti-wrinkle power
2.5 /10
when present at, %
5
in this formula, est. %
6
Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Asiatic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
5.5
Ingredient Est. % Benchmark
Rich in Antioxidants
6
2.5
0.3
0.3
All antioxidants 9.1 3 Rich in antioxidants
All antioxidants
9.1
Ascorbic Acid
6
Hyaluronic Acid
2.5
Asiaticoside
0.3
Arbutin
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
None
All soothing 0 5 No
All soothing
0
None
Benchmark
5

Ingredients explained

Water
Est. %80
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Ascorbic Acid
Est. %6
Function
Origin
Ascorbic Acid

Also known as vitamin C, this multi-benefit ingredient has proven anti-wrinkle, antioxidant, and anti-pigmentation efficacy. It degrades easily when exposed to air and light, so it requires proper packaging to maintain its stability.

Hyaluronic Acid
Est. %2.5
Function
Origin
Hyaluronic Acid

A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.

Pentylene Glycol
Est. %2.4
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Urea
Est. %2
Function
Origin
UreaUrea can be found in urine, skin, and other tissues as a degradation product of proteins. In concentrations below 5%, urea is humectant moisturizing. At concentrations above 10% it is keratolytic, that helps to break away old, flaking, and cracked skin.
Glucose
Est. %1.5
Function
Origin
GlucoseA simple sugar that is also one of two components of sucrose, or table sugar. It is used as a humectant in skincare products. Glucose is also used to flavor lip care cosmetics because of its mildly sweet taste.
Guanidine HCl
Est. %1.3
Function
Origin
Guanidine HCl
Tripeptide-1
Est. %0.3
Function
Origin
Tripeptide-1

A small, skin-identical peptide that boosts collagen renewal in the skin and improves other structural proteins. It may have trouble penetrating the skin in this form, so palmitic acid or biotin is usually added to it.

Arbutin
Est. %0.3
Function
Origin
ArbutinOne of the few potent anti-pigment compounds found naturally in bearberry or cranberry leaves. When applied to the skin, this ingredient converts into hydroquinone, with tyrosinase inhibiting effects.
Polyporus Umbellatus (Mushroom) Extract
Est. %0.3
Function
Origin
Polyporus Umbellatus (Mushroom) Extract
Calcium Pantothenate
Est. %0.3
Function
Origin
Calcium PantothenateA vitamin B5 derivative that reduces static buildup on the skin.
Asiaticoside
Est. %0.3
Function
Origin
Asiaticoside

A Gotu Kola or Centella Asiatica derivative with confirmed anti-wrinkle efficacy.

Asiatic Acid
Est. %0.3
Function
Origin
Asiatic AcidA compound isolated from Gotu Kola, a promising anti-wrinkle medicinal plant from Southeast Asia. It is claimed to increase the production of collagen and help with the wound healing process.
Zinc Sulfate
Est. %0.3
Function
Origin
Zinc Sulfate
Glycerin
Est. %0.3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.