iS Clinical Pro-Heal Serum Advance Review

iS Clinical Pro-Heal Serum Advance
2.2
/ 10
Moisturizing
3.8 Humectancy icon Humectancy
0.5 Occlusivity icon Occlusivity
5Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

iS Clinical Pro-Heal Serum Advance Ingredients

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Full Ingredient List (INCI):

Water, Ascorbic Acid, Laureth-4, Alcohol Denat., Pentylene Glycol, Propylene Glycol, Triethanolamine, Tocopherol, Glycerin, Bioflavonoids, Retinol, Olea Europaea (Olive) Leaf Extract, Zinc Sulfate, Polyporus Umbellatus (Mushroom) Extract, Arbutin, Polysorbate 20, Phenoxyethanol
Review

Does iS Clinical Pro-Heal Serum Advance Work?

 
According to CreamScan's analysis of the ingredient list, here’s what iS Clinical Pro-Heal Serum Advance has to offer:
 
✅ Light moisturizing. It has a moisturizing rating of 2.2 out of 10.
✅ Considerable anti-wrinkle efficacy: iS Clinical Pro-Heal Serum Advance has an anti-wrinkle rating of 5.0 out of 10, indicating a moderate ability to reduce wrinkles.
✅ Antioxidant protection

  

Key Benefits of iS Clinical Pro-Heal Serum Advance

 
These are the key benefits you can expect from using iS Clinical Pro-Heal Serum Advance:
 

🔵 Slight Moisturizing When Used Alone

According to CreamScan analysis, iS Clinical Pro-Heal Serum Advance is lightly moisturizing, with a moisturizing rating of 2.2 out of 10.

Is it more humectant or occlusive? Rather humectant. It has a low occlusivity of 0.5 out of 10 and a moderate humectancy of 3.8 out of 10, primarily due to the high content of Pentylene Glycol (est. ≈2.0%).

This type of product provides relatively light moisturizing on its own but can contribute to overall moisturizing efficacy when used as part of a skincare routine, alongside another moisturizer.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣 Considerable Anti-Wrinkle Efficacy

According to CreamScan analysis, iS Clinical Pro-Heal Serum Advance has a moderate anti-wrinkle rating of 5.0 out of 10.

It contains 2 active ingredients with proven anti-wrinkle efficacy:

1️⃣ Ascorbic Acid (est. ≈6.0%),
 or Vitamin C, a popular ingredient, yet with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 20 participants (Humbert et al.). This study showed that a cream with a relatively high concentration of 5% ascorbic acid reduced the average wrinkle depth by 7% after 6 months of use, compared to a vehicle (the same formulation without ascorbic acid).
 
2️⃣ Retinol (est. ≈0.1%),
 the most effective non-prescription anti-wrinkle ingredient. Numerous clinical studies have shown its positive effects at concentrations as low as 0.1%. A study with 36 participants (Kafi et al.) confirmed that a lotion containing 0.4% retinol reduced wrinkle severity by 21% after 24 weeks of use, compared to the same formulation without retinol (vehicle).
 
Among others, iS Clinical Pro-Heal Serum Advance also contains Olea Europaea (Olive) Leaf Extract, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Olea Europaea (Olive) Leaf Extract provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that Olea Europaea (Olive) Leaf Extract may reduce wrinkles, its efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that iS Clinical Pro-Heal Serum Advance is rich (> 3%) in antioxidants, specifically Ascorbic Acid (est. ≈6.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: iS Clinical Pro-Heal Serum Advance

 
CreamScan identified a few things to consider before adding iS Clinical Pro-Heal Serum Advance to your skincare routine:
 

⚠️ May Increase Skin Photosensitivity Due to Retinol

This product contains retinol, which offers powerful anti-wrinkle benefits. The mechanism behind retinol’s action is boosting cell turnover. This process exposes new, more delicate skin, making it more vulnerable to sun damage.

As a result, using products with retinol may increase the skin's sensitivity, making it more prone to sunburn or irritation when exposed to UV rays.

To protect the skin, dermatologists recommend applying a broad-spectrum sunscreen with at least SPF 30 throughout the duration of retinol treatment, along with avoiding direct sun exposure. Retinol should be used at night, as it is sensitive to sunlight and can lose its potency when exposed to UV rays.

📌 Please always check the manufacturer's instructions for using the retinol-containing products, either on their website or product label.

⚠️ As a Standalone Moisturizer, It Has Relatively Low Moisturizing Potential

If you use iS Clinical Pro-Heal Serum Advance for moisturizing purposes, please keep in mind that it provides relatively light moisturizing on its own, and, more importantly, it’s not optimal for any skin type.

On one hand, it has low occlusivity, which suits oily and combination skin. On the other hand, it has a low estimated concentration of humectants, which are essential for effective moisturizing of all skin types, including oily skin.

Therefore, if used as a standalone moisturizer, this product should be paired with a humectant-rich moisturizer for optimal skin hydration.

Pros & Cons of iS Clinical Pro-Heal Serum Advance

 
Here’s an overview of the pros and cons of iS Clinical Pro-Heal Serum Advance to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

Provides relatively light moisturizing on its own but can contribute to the moisturizing efficacy of any skincare routine
Provides considerable anti-wrinkle efficacy thanks to Ascorbic Acid and Retinol
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

⚠️ May increase skin photosensitivity due to retinol
⚠️ Minimal moisturizing efficacy, even for oily skin - something to keep in mind if this is the only moisturizer in your routine
   

Summary: iS Clinical Pro-Heal Serum Advance

 
Based on the ingredient list analysis, CreamScan AI suggests that iS Clinical Pro-Heal Serum Advance
 is specifically effective in treating wrinkles, containing ingredients with solid, robust evidence of anti-wrinkle efficacy.
 

As a moisturizer, it provides relatively light hydration on its own but can enhance the moisturizing efficacy of any skincare routine.

With its high antioxidant content, iS Clinical Pro-Heal Serum Advance helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about iS Clinical Pro-Heal Serum Advance worth noting.
 
If you use iS Clinical Pro-Heal Serum Advance as your primary moisturizer, please keep in mind that it provides only light hydration, which isn’t actually ideal for any skin type. While its low occlusivity may work for oily and combination skin, it lacks sufficient humectants, which are vital for effective hydration of any skin type. Therefore, for optimal moisturizing results, it should be paired with a humectant-rich moisturizer.
 
This product contains retinol, the most powerful and well-researched non-prescription anti-wrinkle ingredient. However, retinol can make your skin more prone to sun damage and increase sensitivity, so it’s recommended to use a broad-spectrum sunscreen with at least SPF 30 throughout the duration of retinol treatment.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
80
6
4
3
2
1.5
1.3
1
0.3
0.3
0.1
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Ascorbic Acid
Function:
Origin:
Laureth-4
Function:
Origin:
Alcohol Denat.
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Propylene Glycol
Function:
Origin:
Triethanolamine
Function:
Origin:
Tocopherol
Function:
Origin:
Glycerin
Function:
Origin:
Bioflavonoids
Function:
Origin:
Retinol
Function:
Origin:
Olea Europaea (Olive) Leaf Extract
Function:
Origin:
Zinc Sulfate
Function:
Origin:
Polyporus Umbellatus (Mushroom) Extract
Function:
Origin:
Arbutin
Function:
Origin:
Polysorbate 20
Function:
Origin:
Phenoxyethanol
Function:
Origin:

Ratings

All humectants
3.8
2
1.5
0.3
Benchmark
10
All occlusives
1.0
1.0
Benchmark
20
Moisturizing rating
2.2
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 3.8 10
3.8
2
1.5
0.3
Occlusivity All occlusives 1.0 20
0.5
1.0
Moisturizing rating
2.2
Ingredient Est. % Benchmark Humectancy
2
1.5
0.3
All humectants 3.8 10
3.8
All humectants
3.8
2
1.5
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
1
All occlusives 1.0 20
0.5
All occlusives
1.0
1.0
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
2.5 /10 5 6 2.5
10 /10 0.4 0.1 2.5
n/a
- 0.3 -
Total
5
Ascorbic Acid
2.5
Ingredient anti-wrinkle power
2.5 /10
when present at, %
5
in this formula, est. %
6
Retinol
2.5
Ingredient anti-wrinkle power
10 /10
when present at, %
0.4
in this formula, est. %
0.1
Olea Europaea (Olive) Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
5
Ingredient Est. % Benchmark
Rich in Antioxidants
6
1
0.3
0.3
0.3
All antioxidants 7.9 3 Rich in antioxidants
All antioxidants
7.9
Ascorbic Acid
6
Tocopherol
1
Bioflavonoids
0.3
Olea Europaea (Olive) Leaf Extract
0.3
Arbutin
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
All soothing 0.3 5 No
All soothing
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %80
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Ascorbic Acid
Est. %6
Function
Origin
Ascorbic Acid

Also known as vitamin C, this multi-benefit ingredient has proven anti-wrinkle, antioxidant, and anti-pigmentation efficacy. It degrades easily when exposed to air and light, so it requires proper packaging to maintain its stability.

Laureth-4
Est. %4
Function
Origin
Laureth-4A surfactant that can suspend oil droplets in a large water phase. The oils are typically fragrances or other oils added in small amounts. Laureth-4 is listed among common comedogenic ingredients by acne.org.
Alcohol Denat.
Est. %3
Function
Origin
Alcohol Denat.

Denatured alcohol is ethanol that contains additives that make it unsafe to consume. It is mainly used as a solvent and an antimicrobial agent. A major drawback to alcohol denat. is that it dries out the skin.

Pentylene Glycol
Est. %2
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Propylene Glycol
Est. %1.5
Function
Origin
Propylene GlycolA clear, thick, odorless liquid of synthetic origin. Its main function is to stabilize cosmetic products exposed to varying temperatures. It is also a moderately strong humectant with similar properties to glycerin.
Triethanolamine
Est. %1.3
Function
Origin
TriethanolamineA clear, colorless, and highly viscous liquid, this ingredient is an excellent pH adjuster. When it is necessary to neutralize an acidic solution or to generally increase the pH of a product, triethanolamine is a common choice.
Tocopherol
Est. %1
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Glycerin
Est. %0.3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Bioflavonoids
Est. %0.3
Function
Origin
BioflavonoidsA mixture of plant-based compounds commonly referred to as flavonoids. Each flavonoid has slightly different properties, but overall they are potent antioxidant and anti-inflammatory compounds.
Retinol
Est. %0.1
Function
Origin
Retinol

One of the most famous and well-researched anti-aging ingredients with a maximum anti-wrinkle power of 10 out of 10. It is proven to decrease wrinkles and help the skin regain its thickness, firmness, and texture. Retinol is also effective in treating pigmentation issues such as dark spots and acne.

Olea Europaea (Olive) Leaf Extract
Est. %0.3
Function
Origin
Olea Europaea (Olive) Leaf ExtractAn antioxidant and fragrant extract from the leaves of the olive tree. It contains a promising anti-aging compound called Oleuropein, and a prospective anti-pigment compound called Cornoside.
Zinc Sulfate
Est. %0.3
Function
Origin
Zinc Sulfate
Polyporus Umbellatus (Mushroom) Extract
Est. %0.3
Function
Origin
Polyporus Umbellatus (Mushroom) Extract
Arbutin
Est. %0.3
Function
Origin
ArbutinOne of the few potent anti-pigment compounds found naturally in bearberry or cranberry leaves. When applied to the skin, this ingredient converts into hydroquinone, with tyrosinase inhibiting effects.
Polysorbate 20
Est. %0.3
Function
Origin
Polysorbate 20A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.