Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum Review

Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers
Ingredients

Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum Ingredients

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Full Ingredient List (INCI):

Water, Potassium Azeloyl Diglycinate, Propylene Glycol, Niacinamide, Centella Asiatica Leaf Extract, Snail Secretion Filtrate, Glycerin, Ethylhexylglycerin, Hamamelis Virginiana (Witch Hazel) Leaf Extract, Hydroxyethylcellulose, Sodium Hyaluronate, Allantoin
Review

Does Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
✅ Modest anti-wrinkle efficacy: Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.
✅ Soothing: Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
✅ Antioxidant protection

  

Key Benefits of Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum

 
These are the key benefits you can expect from using Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum:
 

🔵 Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Propylene Glycol (est. ≈4.0%) and Niacinamide (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum has a modest level of anti-wrinkle efficacy, rated 3.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈2.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum also contains contains Centella Asiatica Leaf Extract and Snail Secretion Filtrate, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

🔴 Skin Soothing and Calming Potential

Based on the ingredient list analysis, Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum is rich (> 5%) in soothing ingredients, particularly Potassium Azeloyl Diglycinate (est. ≈5.0%) and Niacinamide (est. ≈2.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum

 
CreamScan identified a few things to consider before adding Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum to your skincare routine:
 

⚠️ Contains Snail Secretion Filtrate –  a Popular Ingredient with Limited Proven Clinical Efficacy

Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum contains Snail Secretion Filtrate (SSF, SCA), a purified form of snail mucin. Snail Secretion Filtrate is widely promoted for its supposed skincare benefits, including hydration, skin repair, wound healing, and anti-aging. CreamScan conducted an investigation into clinical trials evaluating the potential efficacy of SSF and found no convincing evidence to support its claimed benefits beyond basic moisturization. The full article is available here.

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum

 
Here’s an overview of the pros and cons of Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Offers modest anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
✅ Potentially soothing, as it contains a high concentration of soothing ingredients like Potassium Azeloyl Diglycinate and Niacinamide
 

⭕ Cons: 

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants

⚠️ Contains Snail Secretion Filtrate (SSF), a popular ingredient with limited clinical evidence supporting most of its claimed benefits.

   

Summary: Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum
, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
Rich in antioxidants, Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation. This product is also formulated with a high concentration of soothing ingredients, offering the potential to calm and comfort irritated skin. Whether you’re experiencing redness, irritation, or general sensitivity, its soothing properties may help restore balance and provide relief.
 
That said, there are some things about Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum worth noting.
 
Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.
 

Note that Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum contains Snail Secretion Filtrate (SSF), an ingredient widely promoted for its supposed skincare benefits, including wound healing and anti-aging. However, a CreamScan investigation of clinical evidence found no convincing data supporting these claims.

📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
80
5
4
2
1.9
1.5
1.3
1
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Potassium Azeloyl Diglycinate
Function:
Origin:
Propylene Glycol
Function:
Origin:
Niacinamide
Function:
Origin:
Centella Asiatica Leaf Extract
Function:
Origin:
Snail Secretion Filtrate
Function:
Origin:
Glycerin
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Hamamelis Virginiana (Witch Hazel) Leaf Extract
Function:
Origin:
Hydroxyethylcellulose
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Allantoin
Function:
Origin:

Ratings

All humectants
10.4
4
2
1.5
1.3
1
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 10.4 10
10.0
4
2
1.5
1.3
1
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
4
2
1.5
1.3
1
0.3
0.3
All humectants 10.4 10
10
All humectants
10.4
4
2
1.5
1.3
1
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 2 3
n/a
- 1.9 -
n/a
- 1.5 -
Total
3
Niacinamide
3
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
2
Centella Asiatica Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1.9
Snail Secretion Filtrate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1.5
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
2
1.9
0.3
All antioxidants 4.2 3 Rich in antioxidants
All antioxidants
4.2
Niacinamide
2
Centella Asiatica Leaf Extract
1.9
Sodium Hyaluronate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
5
2
1.9
0.3
0.3
All soothing 9.5 5 Rich in soothing
All soothing
9.5
5
2
1.9
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %80
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Potassium Azeloyl Diglycinate
Est. %5
Function
Origin
Potassium Azeloyl DiglycinateA modified version of azelaic acid. It reduces signs of redness, hyperpigmentation, and stinging and burning, and is better tolerated, more effective, and more easily incorporated into creams than azelaic acid.
Propylene Glycol
Est. %4
Function
Origin
Propylene GlycolA clear, thick, odorless liquid of synthetic origin. Its main function is to stabilize cosmetic products exposed to varying temperatures. It is also a moderately strong humectant with similar properties to glycerin.
Niacinamide
Est. %2
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Centella Asiatica Leaf Extract
Est. %1.9
Function
Origin
Centella Asiatica Leaf ExtractA well-researched soothing, wound-healing, and promising anti-aging extract that is obtained from the leaves of the Gotu Kola.
Snail Secretion Filtrate
Est. %1.5
Function
Origin
Snail Secretion Filtrate

aka snail mucin, a popular k-beauty ingredient without convincing proof of efficacy.

Glycerin
Est. %1.3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Ethylhexylglycerin
Est. %1
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Hamamelis Virginiana (Witch Hazel) Leaf Extract
Est. %0.3
Function
Origin
Hamamelis Virginiana (Witch Hazel) Leaf ExtractComing from witch hazel leaves, this potent astringent and anti-inflammatory extract contains a mixture of various tannins and flavonoids, as well as a small amount of essential oil with a mild, spicy aroma.
Hydroxyethylcellulose
Est. %0.3
Function
Origin
HydroxyethylcelluloseA naturally-derived thickener that can form clear gel textures without the slimy feeling, unlike some other natural gel-formers.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Allantoin
Est. %0.3
Function
Origin
AllantoinA fluffy, white powder that acts as a humectant due to its water-loving chemistry and as an exfoliant that helps to remove dead skin cells. It has also been shown to be very soothing to irritated and inflamed skin.