Replenix Retinol 10X Regenerate Dry Serum Review

Replenix Retinol 10X Regenerate Dry Serum
5.2
/ 10
Moisturizing
0.3 Humectancy icon Humectancy
10.0 Occlusivity icon Occlusivity
2.5Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

Replenix Retinol 10X Regenerate Dry Serum Ingredients

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Full Ingredient List (INCI):

Cyclopentasiloxane, Caprylyl Methicone, Dimethicone Crosspolymer, PEG-12 Dimethicone/PPG-20 Crosspolymer, Disiloxane, Caffeine, PEG/PPG-18/18 Dimethicone, Camellia Sinensis Polyphenols, Retinol, Sodium Hyaluronate, Polysorbate 20, Cyclomethicone
Review

Does Replenix Retinol 10X Regenerate Dry Serum Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Replenix Retinol 10X Regenerate Dry Serum has to offer:
 
✅ Strong occlusive moisturizing. This exceptionally occlusive moisturizer, ideal for dry and very dry skin, has a moderate moisturizing rating of 5.2 out of 10, impaired by the lack of humectants.
✅ Modest anti-wrinkle efficacy: Replenix Retinol 10X Regenerate Dry Serum has an anti-wrinkle rating of 2.5 out of 10 so you may expect some, although limited, effect on wrinkles.
✅ Antioxidant protection

  

Key Benefits of Replenix Retinol 10X Regenerate Dry Serum

 
These are the key benefits you can expect from using Replenix Retinol 10X Regenerate Dry Serum:
 

🔵🔵🔵 Exceptionally Rich Moisturizer with the Right Occlusivity for Very Dry Skin

According to CreamScan analysis, Replenix Retinol 10X Regenerate Dry Serum is quite moisturizing, with a moisturizing rating of 5.2 out of 10.

Is it more humectant or occlusive? Significantly more occlusive. It has a low Humectancy of 0.3 out of 10 and a maximum Occlusivity of 10 out of 10, entirely due to the high content of Caprylyl Methicone (est. ≈22.0%).

This type of product, when used as a standalone moisturizer, can deliver an exceptional level of occlusive hydration that is adequate for dry to very skin. The occlusive profile of Replenix Retinol 10X Regenerate Dry Serum suggests a rich, thick texture, making it perfectly suited for dry skin.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Replenix Retinol 10X Regenerate Dry Serum has a modest level of anti-wrinkle efficacy, rated 2.5 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Retinol (est. ≈0.1%),
 the most effective non-prescription anti-wrinkle ingredient. Numerous clinical studies have shown its positive effects at concentrations as low as 0.1%. A study with 36 participants (Kafi et al.) confirmed that a lotion containing 0.4% retinol reduced wrinkle severity by 21% after 24 weeks of use, compared to the same formulation without retinol (vehicle).
 
Among others, Replenix Retinol 10X Regenerate Dry Serum also contains Caffeine, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Caffeine provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that Caffeine may reduce wrinkles, its efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Replenix Retinol 10X Regenerate Dry Serum is rich (> 3%) in antioxidants, specifically Caffeine (est. ≈3.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Replenix Retinol 10X Regenerate Dry Serum

 
CreamScan identified a few things to consider before adding Replenix Retinol 10X Regenerate Dry Serum to your skincare routine:
 

⚠️ May Increase Skin Photosensitivity Due to Retinol

This product contains retinol, which offers powerful anti-wrinkle benefits. The mechanism behind retinol’s action is boosting cell turnover. This process exposes new, more delicate skin, making it more vulnerable to sun damage.

As a result, using products with retinol may increase the skin's sensitivity, making it more prone to sunburn or irritation when exposed to UV rays.

To protect the skin, dermatologists recommend applying a broad-spectrum sunscreen with at least SPF 30 throughout the duration of retinol treatment, along with avoiding direct sun exposure. Retinol should be used at night, as it is sensitive to sunlight and can lose its potency when exposed to UV rays.

📌 Please always check the manufacturer's instructions for using the retinol-containing products, either on their website or product label.

⚠️ Best for Very Dry Skin - May Be Too Thick for Other Skin Types

With exceptional occlusivity, this product is optimal for moisturizing dry and very dry skin but may be too thick for other skin types, including normal, and especially combination and oily skin.

If you have oily, combination, or normal skin and are considering purchasing this product for the first time, it might be a good idea to try a sample before buying.

⚠️ Needs to Be Paired with Extra Humectants for Optimal Moisturizing Efficacy

An ideal moisturizer for any skin type should balance the right level of occlusivity (depending on skin type) with a significant amount of humectants, while Replenix Retinol 10X Regenerate Dry Serum contains a low level of humectants.

People with dry skin would definitely benefit from adding more humectants to their moisturizing routine beyond what this product offers. If this is your only moisturizer, it may be worth including a humectant-rich product, such as a serum, in your skincare routine.

Pros & Cons of Replenix Retinol 10X Regenerate Dry Serum

 
Here’s an overview of the pros and cons of Replenix Retinol 10X Regenerate Dry Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

Exceptionally rich moisturizer with the right level of occlusivity to moisturize dry to very dry skin
Offers modest anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

⚠️ May increase skin photosensitivity due to retinol
⚠️ May feel too rich and thick on skin types other than dry
⚠️ Only if used as a standalone moisturizer - needs to be paired with extra humectants for optimal moisturizing efficacy
   

Summary: Replenix Retinol 10X Regenerate Dry Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Replenix Retinol 10X Regenerate Dry Serum
, as a moisturizer, provides an exceptional level of occlusive hydration that is adequate for dry to very skin, delivered in a rich, thick texture.
 
Replenix Retinol 10X Regenerate Dry Serum contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
With its high antioxidant content, Replenix Retinol 10X Regenerate Dry Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about Replenix Retinol 10X Regenerate Dry Serum worth noting.
 
With its high occlusivity, Replenix Retinol 10X Regenerate Dry Serum is ideal for dry skin but may feel too thick on other skin types. If you have oily, combination, or normal skin, it’s a good idea to try a sample before purchasing.
 
If you use this product as your only moisturizer in a routine, please note that it contains only a small amount of humectants. Regardless of your skin type, adding extra humectants can enhance optimal moisturizing efficacy. Therefore, it may be worth pairing Replenix Retinol 10X Regenerate Dry Serum with a humectant-rich product, such as a serum, in your skincare routine.
 
This product contains retinol, the most powerful and well-researched non-prescription anti-wrinkle ingredient. However, retinol can make your skin more prone to sun damage and increase sensitivity, so it’s recommended to use a broad-spectrum sunscreen with at least SPF 30 throughout the duration of retinol treatment.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
50
22
11
6
4
3
2
1.5
0.1
0.3
0.3
0.3
Est. %
Cyclopentasiloxane
Function:
Origin:
Caprylyl Methicone
Function:
Origin:
Dimethicone Crosspolymer
Function:
Origin:
PEG-12 Dimethicone/PPG-20 Crosspolymer
Function:
Origin:
Disiloxane
Function:
Origin:
Caffeine
Function:
Origin:
PEG/PPG-18/18 Dimethicone
Function:
Origin:
Camellia Sinensis Polyphenols
Function:
Origin:
Retinol
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Polysorbate 20
Function:
Origin:
Cyclomethicone
Function:
Origin:

Ratings

All humectants
0.3
0.3
Benchmark
10
All occlusives
22.0
22.0
Benchmark
20
Moisturizing rating
5.2
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 0.3 10
0.3
0.3
Occlusivity All occlusives 22.0 20
10.0
22.0
Moisturizing rating
5.2
Ingredient Est. % Benchmark Humectancy
0.3
All humectants 0.3 10
0.3
All humectants
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
22
All occlusives 22.0 20
10.0
All occlusives
22.0
22.0
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
10 /10 0.4 0.1 2.5
n/a
- 3 -
Total
2.5
Retinol
2.5
Ingredient anti-wrinkle power
10 /10
when present at, %
0.4
in this formula, est. %
0.1
Caffeine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
3
Anti-wrinkle rating
2.5
Ingredient Est. % Benchmark
Rich in Antioxidants
3
1.5
0.3
All antioxidants 4.8 3 Rich in antioxidants
All antioxidants
4.8
Caffeine
3
Camellia Sinensis Polyphenols
1.5
Sodium Hyaluronate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
None
All soothing 0 5 No
All soothing
0
None
Benchmark
5

Ingredients explained

Cyclopentasiloxane
Est. %50
Function
Origin
CyclopentasiloxaneA lightweight, fast-spreading emollient that leaves a very soft and silky after-feel on the skin. Supplied as a clear and colorless liquid, cyclopentasiloxane is often used as a solvent to dissolve other silicones in.
Caprylyl Methicone
Est. %22
Function
Origin
Caprylyl MethiconeA liquid silicone with occlusive moisturizing properties. Being compatible with natural oils is a challenge for most silicones, but caprylyl methicone plays well with all types of oils.
Dimethicone Crosspolymer
Est. %11
Function
Origin
Dimethicone CrosspolymerA group of ingredients that are typically added to skincare products to adjust the formula. Dimethicone Crosspolymers stabilize a formula, regulate its thickness and consistency and give the product a velvety feel.
PEG-12 Dimethicone/PPG-20 Crosspolymer
Est. %6
Function
Origin
PEG-12 Dimethicone/PPG-20 Crosspolymer
Disiloxane
Est. %4
Function
Origin
Disiloxane
Caffeine
Est. %3
Function
Origin
CaffeineAn antioxidant compound that is obtained from coffee and tea leaves. It increases the microcirculation of blood in the skin and is claimed to be able to reduce the appearance of orange peel skin (although the research is lacking).
PEG/PPG-18/18 Dimethicone
Est. %2
Function
Origin
PEG/PPG-18/18 DimethiconeA silicone-based emulsifier that has the ability to create non-sticky and non-greasy formulas.
Camellia Sinensis Polyphenols
Est. %1.5
Function
Origin
Camellia Sinensis Polyphenols
Retinol
Est. %0.1
Function
Origin
Retinol

One of the most famous and well-researched anti-aging ingredients with a maximum anti-wrinkle power of 10 out of 10. It is proven to decrease wrinkles and help the skin regain its thickness, firmness, and texture. Retinol is also effective in treating pigmentation issues such as dark spots and acne.

Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Polysorbate 20
Est. %0.3
Function
Origin
Polysorbate 20A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
Cyclomethicone
Est. %0.3
Function
Origin
CyclomethiconeA blend of emollient silicones that leaves a smooth and non-greasy after-feel. Unlike other types of oils, it does not leave any residue on the skin, which is part of what makes it so popular.