Neutrogena On-the-Spot Acne Treatment Ingredients + Evidence-Based Efficacy Review

Neutrogena On-the-Spot Acne Treatment Ingredients

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Full Ingredient List (INCI):

Water, Carbomer, Benzoyl Peroxide, Ethylhexylglycerin, Sodium Hydroxide, Chlorphenesin, Disodium EDTA, Laureth-4, Hydroxypropyl Methylcellulose

Review

Does Neutrogena On-the-Spot Acne Treatment Work?

According to CreamScan's analysis of the ingredient list, here’s what Neutrogena On-the-Spot Acne Treatment has to offer:

✅ A bit of moisturizing. It has a moisturizing rating of 1.0 out of 10.

Key Benefits of Neutrogena On-the-Spot Acne Treatment

These are the key benefits you can expect from using Neutrogena On-the-Spot Acne Treatment:

🔵 Slight Moisturizing When Used Alone

According to CreamScan analysis, Neutrogena On-the-Spot Acne Treatment is slightly moisturizing, with a moisturizing rating of 1.0 out of 10.

Is it more humectant or occlusive? This product is purely humectant, but with a low Humectancy of 2.0 out of 10. It has zero Occlusivity as we didn't find any occlusive ingredients on the ingredient list.

This type of product provides relatively light moisturizing on its own but can contribute to overall moisturizing efficacy when used as part of a skincare routine, alongside another moisturizer.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Neutrogena On-the-Spot Acne Treatment

Here’s an overview of the pros and cons of Neutrogena On-the-Spot Acne Treatment to help you decide if it’s the right choice for your skincare routine:

🟩 Pros:

✅ Provides relatively light moisturizing on its own but can contribute to the moisturizing efficacy of any skincare routine

⭕ Cons:

✅ We couldn't find any

Summary: Neutrogena On-the-Spot Acne Treatment

Based on the ingredient list analysis, CreamScan AI suggests that Neutrogena On-the-Spot Acne Treatment

, as a moisturizer, provides relatively light hydration on its own but can enhance the moisturizing efficacy of any skincare routine.

📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

Est. % The Estimated % is our algorithm-based assumption about an ingredient's concentration in a formula. Learn more The Estimated % is our algorithm-based assumption about an ingredient's concentration in a formula. Learn more	Ingredient	Origin	Functions
85	Water The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients. Water The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.	Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water.	Formula helper Solvent – a liquid that dissolves other ingredients. Formula helper Solvent – a liquid that dissolves other ingredients.
6	Carbomer A synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer. Carbomer A synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Formula helper Emulsion stabilizing – increases the stability of a formula. Gel-forming – helps to create a gel by swelling. Viscosity controlling – changes the thickness of a product. Formula helper Emulsion stabilizing – increases the stability of a formula. Gel-forming – helps to create a gel by swelling. Viscosity controlling – changes the thickness of a product.
2.5 Verified concentration of an ingredient as indicated on its package, in the ingredient list, or on the official website. Verified concentration of an ingredient as indicated on its package, in the ingredient list, or on the official website.	Benzoyl Peroxide Benzoyl Peroxide		Anti-Acne Anti-acne agents treat acne blemishes, blackheads, and whiteheads. Anti-Acne Anti-acne agents treat acne blemishes, blackheads, and whiteheads. Formula helper Oxidizing – oxidizes substances by accepting electrons. Formula helper Oxidizing – oxidizes substances by accepting electrons.
2	Ethylhexylglycerin A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin. Ethylhexylglycerin A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Preservative Preservatives prevent the growth of bacteria and fungi in a product. Preservative Preservatives prevent the growth of bacteria and fungi in a product.
1.9	Sodium Hydroxide An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin. Sodium Hydroxide An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Formula helper Denaturant – turns alcohol undrinkable. pH adjuster – alters the pH level of a formula. Formula helper Denaturant – turns alcohol undrinkable. pH adjuster – alters the pH level of a formula.
0.3	Chlorphenesin A preservative and broad-spectrum antimicrobial agent that protects products from a wide range of bacteria and fungi. Chlorphenesin A preservative and broad-spectrum antimicrobial agent that protects products from a wide range of bacteria and fungi.	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Preservative Preservatives prevent the growth of bacteria and fungi in a product. Preservative Preservatives prevent the growth of bacteria and fungi in a product.
0.3	Disodium EDTA A synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions. Disodium EDTA A synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Formula helper Chelating – deactivates harmful heavy metal ions. Viscosity controlling – changes the thickness of a product. Formula helper Chelating – deactivates harmful heavy metal ions. Viscosity controlling – changes the thickness of a product.
0.3	Laureth-4 A surfactant that can suspend oil droplets in a large water phase. The oils are typically fragrances or other oils added in small amounts. Laureth-4 is listed among common comedogenic ingredients by acne.org. Laureth-4 A surfactant that can suspend oil droplets in a large water phase. The oils are typically fragrances or other oils added in small amounts. Laureth-4 is listed among common comedogenic ingredients by acne.org.	Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Formula helper Antistatic – reduces electric charge buildup. Emulsifying – helps to mix water and oil together. Formula helper Antistatic – reduces electric charge buildup. Emulsifying – helps to mix water and oil together.
0.3	Hydroxypropyl Methylcellulose A natural viscosity controlling agent that is commonly used in skin cleansing products to thicken the consistency. It also functions as an emulsion stabilizing agent and binding agent. Hydroxypropyl Methylcellulose A natural viscosity controlling agent that is commonly used in skin cleansing products to thicken the consistency. It also functions as an emulsion stabilizing agent and binding agent.	Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Formula helper Adhesive – allows products to better stick to the skin. Antistatic – reduces electric charge buildup. Binding – bonds ingredients together. Emulsion stabilizing – increases the stability of a formula. Film-forming – creates a film to increase wear time. Viscosity controlling – changes the thickness of a product. Formula helper Adhesive – allows products to better stick to the skin. Antistatic – reduces electric charge buildup. Binding – bonds ingredients together. Emulsion stabilizing – increases the stability of a formula. Film-forming – creates a film to increase wear time. Viscosity controlling – changes the thickness of a product.

Water

Function:

Origin:

Carbomer

Function:

Origin:

2.5

Benzoyl Peroxide

Function:

Origin:

Ethylhexylglycerin

Function:

Origin:

1.9

Sodium Hydroxide

Function:

Origin:

0.3

Chlorphenesin

Function:

Origin:

0.3

Disodium EDTA

Function:

Origin:

0.3

Laureth-4

Function:

Origin:

0.3

Hydroxypropyl Methylcellulose

Function:

Origin:

Ratings

Ethylhexylglycerin

Benchmark

None

Benchmark

Moisturizing rating

1.0

Ingredient		Est. %	Benchmark Sciense based points to which we compare all humectants and all occlusives in a product to calculate its Humectancy and Occlusivity. Sciense based points to which we compare all humectants and all occlusives in a product to calculate its Humectancy and Occlusivity.	Raiting
Humectancy	All humectants	2	10	2.0
	Ethylhexylglycerin A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin. Ethylhexylglycerin A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.	2
Occlusivity	All occlusives	0.0	20	0.0
	None
Moisturizing rating				1.0

Ingredient	Est. %	Benchmark According to various studies, a formula made up of 10% humectants will significantly increase skin hydration. Some studies also suggest that any further icrease in the consentration of humectants does not translate inty any more hydration and may even be dehydrating. To achieve maximum Humectancy, the product should have humectants with a total score of 10 and more. According to various studies, a formula made up of 10% humectants will significantly increase skin hydration. Some studies also suggest that any further icrease in the consentration of humectants does not translate inty any more hydration and may even be dehydrating. To achieve maximum Humectancy, the product should have humectants with a total score of 10 and more.	Humectancy
Ethylhexylglycerin A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin. Ethylhexylglycerin A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.	2
All humectants	2	10	2

Ethylhexylglycerin

Benchmark

Ingredient	Est. %	Benchmark The most occlusive product possible is 100% petrolatum (hello Vaseline Jelly). According to studies, hovewer, even 10% petrolatum can achieve almost the same mosturizing effect. The occlusive properties of petrolatum are at least twice as superior as other occlusive ingredients. This is why, in order to match the moisturizing efficacy of 10% petrolatum, a product needs to contain at least 20% of other occlusives. Our benchmark for maximum Occlusivity is 20 (and the petrolatum score is always doubled). The most occlusive product possible is 100% petrolatum (hello Vaseline Jelly). According to studies, hovewer, even 10% petrolatum can achieve almost the same mosturizing effect. The occlusive properties of petrolatum are at least twice as superior as other occlusive ingredients. This is why, in order to match the moisturizing efficacy of 10% petrolatum, a product needs to contain at least 20% of other occlusives. Our benchmark for maximum Occlusivity is 20 (and the petrolatum score is always doubled).	Occlusivity
None
All occlusives	0.0	20	0.0

None

Benchmark

Ingredient	Ingredient anti-wrinkle power Shows on a scale of 0-10 how effective an ingredient is at reducing wrinkles. Both the Reported Efficacy of the ingredient and the Strength of Evidence are taken into account. Shows on a scale of 0-10 how effective an ingredient is at reducing wrinkles. Both the Reported Efficacy of the ingredient and the Strength of Evidence are taken into account.	when present at, %	in this formula est. %	Rating
None
Total				0

None

Anti-wrinkle rating

Ingredient	Est. %	Benchmark It differs from one antioxidant ingredient to another, but, on average, the research suggests that topically applied antioxidants are effective in consentrations of 3% or above. Any product with a total antioxidant score of 3 or more is considered to be reach in antioxidants. It differs from one antioxidant ingredient to another, but, on average, the research suggests that topically applied antioxidants are effective in consentrations of 3% or above. Any product with a total antioxidant score of 3 or more is considered to be reach in antioxidants.	Rich in Antioxidants
None
All antioxidants	0	3	No

None

Benchmark

Ingredient	Est. %	Benchmark The effective concentration of soothing ingredients varies, but we consider a product rich in soothing ingredients if their estimated concentration is equal to or higher than 5%. The effective concentration of soothing ingredients varies, but we consider a product rich in soothing ingredients if their estimated concentration is equal to or higher than 5%.	Rich in Soothing
None
All soothing	0	5	No

None

Benchmark

Ingredients explained

Water
Est. %	85
Function	Solvent Solvent – a liquid that dissolves other ingredients. Solvent Solvent – a liquid that dissolves other ingredients.
Origin	Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water.

The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.

Carbomer
Est. %	6
Function	Emulsion Stabilizing, Emulsion stabilizing – increases the stability of a formula. Emulsion Stabilizing, Emulsion stabilizing – increases the stability of a formula. Gel-Forming, Gel-forming – helps to create a gel by swelling. Gel-Forming, Gel-forming – helps to create a gel by swelling. Viscosity Controlling Viscosity controlling – changes the thickness of a product. Viscosity Controlling Viscosity controlling – changes the thickness of a product.
Origin	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

A synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.

Benzoyl Peroxide
Est. %	2.5
Function	Anti-Acne, Anti-acne agents treat acne blemishes, blackheads, and whiteheads. Anti-Acne, Anti-acne agents treat acne blemishes, blackheads, and whiteheads. Oxidizing Oxidizing – oxidizes substances by accepting electrons. Oxidizing Oxidizing – oxidizes substances by accepting electrons.
Origin

Ethylhexylglycerin
Est. %	2
Function	Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Preservative Preservatives prevent the growth of bacteria and fungi in a product. Preservative Preservatives prevent the growth of bacteria and fungi in a product.
Origin	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.

Sodium Hydroxide
Est. %	1.9
Function	Denaturant, Denaturant – turns alcohol undrinkable. Denaturant, Denaturant – turns alcohol undrinkable. pH Adjuster pH adjuster – alters the pH level of a formula. pH Adjuster pH adjuster – alters the pH level of a formula.
Origin	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Chlorphenesin
Est. %	0.3
Function	Antimicrobial, Antimicrobials prevent the growth of harmful microorganisms on the skin. Antimicrobial, Antimicrobials prevent the growth of harmful microorganisms on the skin. Preservative Preservatives prevent the growth of bacteria and fungi in a product. Preservative Preservatives prevent the growth of bacteria and fungi in a product.
Origin	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

A preservative and broad-spectrum antimicrobial agent that protects products from a wide range of bacteria and fungi.

Disodium EDTA
Est. %	0.3
Function	Chelating, Chelating – deactivates harmful heavy metal ions. Chelating, Chelating – deactivates harmful heavy metal ions. Viscosity Controlling Viscosity controlling – changes the thickness of a product. Viscosity Controlling Viscosity controlling – changes the thickness of a product.
Origin	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

A synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.

Laureth-4
Est. %	0.3
Function	Fragrance, Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance, Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Antistatic, Antistatic – reduces electric charge buildup. Antistatic, Antistatic – reduces electric charge buildup. Emulsifying Emulsifying – helps to mix water and oil together. Emulsifying Emulsifying – helps to mix water and oil together.
Origin	Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

A surfactant that can suspend oil droplets in a large water phase. The oils are typically fragrances or other oils added in small amounts. Laureth-4 is listed among common comedogenic ingredients by acne.org.

Hydroxypropyl Methylcellulose
Est. %	0.3
Function	Adhesive, Adhesive – allows products to better stick to the skin. Adhesive, Adhesive – allows products to better stick to the skin. Antistatic, Antistatic – reduces electric charge buildup. Antistatic, Antistatic – reduces electric charge buildup. Binding, Binding – bonds ingredients together. Binding, Binding – bonds ingredients together. Emulsion Stabilizing, Emulsion stabilizing – increases the stability of a formula. Emulsion Stabilizing, Emulsion stabilizing – increases the stability of a formula. Film-Forming, Film-forming – creates a film to increase wear time. Film-Forming, Film-forming – creates a film to increase wear time. Viscosity Controlling Viscosity controlling – changes the thickness of a product. Viscosity Controlling Viscosity controlling – changes the thickness of a product.
Origin	Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

A natural viscosity controlling agent that is commonly used in skin cleansing products to thicken the consistency. It also functions as an emulsion stabilizing agent and binding agent.