ISANA Niacinamide Serum

ISANA Niacinamide Serum
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
6.8Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers

Review

Does ISANA Niacinamide Serum work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using ISANA Niacinamide Serum:

  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
  • Significant anti-wrinkle efficacy. With an anti-wrinkle rating of 6.8 out of 10, ISANA Niacinamide Serum is effective in minimizing wrinkles.
  • Soothing: ISANA Niacinamide Serum contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
  • Antioxidant protection.

Lightweight moisturizer ideal for oily skin and a humectant boost for any skincare routine

According to CreamScan analysis, ISANA Niacinamide Serum is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Niacinamide (est. ≈5.0%), Methylpropanediol (est. ≈4.0%) and Glycerin (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

Tip: Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Significant anti-wrinkle efficacy

According to CreamScan analysis, ISANA Niacinamide Serum has a high anti-wrinkle rating of 6.8 out of 10.

It contains 2 active ingredients with proven anti-wrinkle efficacy:

  • Niacinamide (est. ≈5.0%),
     one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
  • Sodium Salicylate (est. ≈0.3%),
     a sodium salt of salicylic acid, with moderate anti-wrinkle efficacy confirmed by a single clinical study involving 30 participants (Merinville et al.). This study found that a cream containing 1% sodium salicylate reduced the average depth of periorbital wrinkles by 7% after 8 weeks of use, compared to a vehicle (the same formulation without sodium salicylate).

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in skin-protecting antioxidants

We estimate that ISANA Niacinamide Serum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈5.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Skin soothing and calming potential

Based on the ingredient list analysis, ISANA Niacinamide Serum is rich (> 5%) in soothing ingredients, particularly Niacinamide (est. ≈5.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

Ingredients

Est. % Ingredient Origin Functions
80
5
4
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Niacinamide
Function:
Origin:
Methylpropanediol
Function:
Origin:
Glycerin
Function:
Origin:
Propylene Glycol
Function:
Origin:
Xanthan Gum
Function:
Origin:
Aspartic Acid
Function:
Origin:
Sodium Salicylate
Function:
Origin:
Citric Acid
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Tetrasodium Iminodisuccinate
Function:
Origin:
Fumaric Acid
Function:
Origin:
Maleic Acid
Function:
Origin:
Malic Acid
Function:
Origin:

Ratings

All humectants
14.3
5
4
3
2
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 14.3 10
10.0
5
4
3
2
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
5
4
3
2
0.3
All humectants 14.3 10
10
All humectants
14.3
5
4
3
2
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 5 6
2.5 /10 1 0.3 0.8
Total
6.8
Niacinamide
6
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
5
Sodium Salicylate
0.8
Ingredient anti-wrinkle power
2.5 /10
when present at, %
1
in this formula, est. %
0.3
Anti-wrinkle rating
6.8
Ingredient Est. % Benchmark
Rich in Antioxidants
5
All antioxidants 5 3 Rich in antioxidants
All antioxidants
5
Niacinamide
5
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
5
All soothing 5 5 Rich in soothing
All soothing
5
5
Benchmark
5

Ingredients explained

Water
Est. %80
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Niacinamide
Est. %5
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Methylpropanediol
Est. %4
Function
Origin
MethylpropanediolMethylpropanediol is a unique glycol that contains two primary hydroxyl groups. That makes methylpropanediol a powerful humectant and an excellent solvent.
Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Propylene Glycol
Est. %2
Function
Origin
Propylene GlycolA clear, thick, odorless liquid of synthetic origin. Its main function is to stabilize cosmetic products exposed to varying temperatures. It is also a moderately strong humectant with similar properties to glycerin.
Xanthan Gum
Est. %1.5
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Aspartic Acid
Est. %0.3
Function
Origin
Aspartic AcidA humectant moisturizing amino acid that is a part of the skin's Natural Moisturizing Factor. It helps to retain water on the skin’s surface and is slightly acidic, thereby helping to balance the pH of a skincare product.
Sodium Salicylate
Est. %0.3
Function
Origin
Sodium Salicylate

A synthetic derivative of salicylic acid with confirmed anti-wrinkle efficacy.

Citric Acid
Est. %0.3
Function
Origin
Citric AcidA gently exfoliating AHA that helps to remove the top layer of dead skin cells. In comparison to other AHAs, citric acid has been shown to be one of the least effective. It is also very commonly used as a stabilizing and pH-controlling agent.
Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Tetrasodium Iminodisuccinate
Est. %0.3
Function
Origin
Tetrasodium Iminodisuccinate
Fumaric Acid
Est. %0.3
Function
Origin
Fumaric Acid
Maleic Acid
Est. %0.3
Function
Origin
Maleic Acid
Malic Acid
Est. %0.3
Function
Origin
Malic AcidA simple organic alpha-hydroxy acid (AHA) commonly found in unripe fruits. It is more gentle of an exfoliant when compared to the famous and potent glycolic and lactic acids.