iS Clinical Hydra-Cool Serum Review

iS Clinical Hydra-Cool Serum
2.4
/ 10
Moisturizing
4.8 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Review

Does iS Clinical Hydra-Cool Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what iS Clinical Hydra-Cool Serum has to offer:
 
  • Light moisturizing. It has a moisturizing rating of 2.4 out of 10.
  • Modest anti-wrinkle efficacy: iS Clinical Hydra-Cool Serum has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.

Key Benefits of iS Clinical Hydra-Cool Serum

 
These are the key benefits you can expect from using iS Clinical Hydra-Cool Serum:
 

Lightweight Purely Humectant Moisturizer Suitable for Oily Skin

According to CreamScan analysis, iS Clinical Hydra-Cool Serum is lightly moisturizing, with a moisturizing rating of 2.4 out of 10.

Is it more humectant or occlusive? Purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a moderate humectancy of 4.8 out of 10, due to the high content of Sodium Hyaluronate (est. ≈2.5%) and Pentylene Glycol (est. ≈2.3%).

This product, when used alone as a moisturizer, can provide light humectant hydration in a fast-absorbing formula without any occlusive ingredients. This could work for people with oily skin who need a basic level of hydration.

Tip: Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

A Humectant Add-on for Any Skincare Routine

But it’s not limited to oily skin - since it contains a moderate amount of humectants, such a humectant add-on will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, iS Clinical Hydra-Cool Serum has a modest level of anti-wrinkle efficacy, rated 3.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Asiaticoside (est. ≈1.0%), 
 derived from the plant Centella asiatica, an ingredient with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 27 participants (Lee et al.). This study demonstrated that a cream containing 0.1% asiaticoside reduced the average wrinkle depth by 8% after 12 weeks of use, compared to a vehicle (the same formulation without asiaticoside).
 
Among others, iS Clinical Hydra-Cool Serum also contains contains Asiatic Acid and Madecassic Acid, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that iS Clinical Hydra-Cool Serum is rich (> 3%) in antioxidants, specifically Sodium Hyaluronate (est. ≈2.5%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: iS Clinical Hydra-Cool Serum

 
CreamScan AI identified a few things to consider before adding iS Clinical Hydra-Cool Serum to your skincare routine:
 

If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using iS Clinical Hydra-Cool Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of iS Clinical Hydra-Cool Serum

 
Here’s an overview of the pros and cons of iS Clinical Hydra-Cool Serum to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Suitable for moisturizing oily skin
  • Lightweight texture
  • Can enhance the moisturizing efficacy of any skincare routine
  • Offers modest anti-wrinkle efficacy
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage such as UV radiation and pollution

Cons: 

  • Needs occlusives to seal in humectants if used as a standalone moisturizer

Ingredients

Est. % Ingredient Origin Functions
85
2.5
2.4
2.3
2
1
1
1
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Calcium Pantothenate
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Menthol
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Asiaticoside
Function:
Origin:
Polyporus Umbellatus (Mushroom) Extract
Function:
Origin:
Asiatic Acid
Function:
Origin:
Madecassic Acid
Function:
Origin:
Blue 1 (CI 42090)
Function:
Origin:

Ratings

All humectants
4.8
2.5
2.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
2.4
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 4.8 10
4.8
2.5
2.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
2.4
Ingredient Est. % Benchmark Humectancy
2.5
2.3
All humectants 4.8 10
4.8
All humectants
4.8
2.5
2.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
3 /10 0.1 1 3
n/a
- 0.3 -
n/a
- 0.3 -
Total
3
Asiaticoside
3
Ingredient anti-wrinkle power
3 /10
when present at, %
0.1
in this formula, est. %
1
Asiatic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Madecassic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
2.5
1
All antioxidants 3.5 3 Rich in antioxidants
All antioxidants
3.5
Sodium Hyaluronate
2.5
Asiaticoside
1
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
2
All soothing 2 5 No
All soothing
2
2
Benchmark
5

Ingredients explained

Water
Est. %85
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Sodium Hyaluronate
Est. %2.5
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Calcium Pantothenate
Est. %2.4
Function
Origin
Calcium PantothenateA vitamin B5 derivative that reduces static buildup on the skin.
Pentylene Glycol
Est. %2.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Menthol
Est. %2
Function
Origin
MentholA volatile compound isolated from peppermint oil. It causes a cooling sensation on the skin that can be very soothing. Menthol can also act as a topical painkiller. In more sensitive individuals, however, it may cause skin irritation or an allergy.
Phenoxyethanol
Est. %1
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Asiaticoside
Est. %1
Function
Origin
Asiaticoside

A Gotu Kola or Centella Asiatica derivative with confirmed anti-wrinkle efficacy.

Polyporus Umbellatus (Mushroom) Extract
Est. %1
Function
Origin
Polyporus Umbellatus (Mushroom) Extract
Asiatic Acid
Est. %0.3
Function
Origin
Asiatic AcidA compound isolated from Gotu Kola, a promising anti-wrinkle medicinal plant from Southeast Asia. It is claimed to increase the production of collagen and help with the wound healing process.
Madecassic Acid
Est. %0.3
Function
Origin
Madecassic AcidAn isolated bioactive compound from Gotu Kola. It increases collagen and hyaluronic acid production in the skin and helps to treat wounds, scars, and burns.
Blue 1 (CI 42090)
Est. %0.3
Function
Origin
Blue 1 (CI 42090)A synthetic dye commonly known as Brilliant Blue FCF that produces rich blue colors for various cosmetic uses. FD&C Blue #1 can also be found in foods, medications, and dietary supplements, as it is considered non-toxic and safe for use.