Calecim Professional Professional Serum | Unbiased Science-Based Efficacy Review

Review

Does Calecim Professional Professional Serum Work?

According to CreamScan AI's analysis of the ingredient list, here’s what Calecim Professional Professional Serum has to offer:

✅ Light moisturizing. It has a moisturizing rating of 3.0 out of 10.

✅ Antioxidant protection

Key Benefits of Calecim Professional Professional Serum

These are the key benefits you can expect from using Calecim Professional Professional Serum:

🔵 Lightweight Purely Humectant Moisturizer Well-Suited for Oily Skin

According to CreamScan analysis, Calecim Professional Professional Serum is lightly moisturizing, with a moisturizing rating of 3.0 out of 10.

Is it more humectant or occlusive? Purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a high humectancy of 6.0 out of 10, primarily due to the high content of Hyaluronic Acid (est. ≈2.5%) and Soluble Collagen (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is well-suited for oily skin, providing moderate hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Enhancement for Any Skincare Routine

But it’s not limited to oily skin - such a humectant enhancement will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Calecim Professional Professional Serum is rich (> 3%) in antioxidants, specifically Hyaluronic Acid (est. ≈2.5%) and Glycoproteins (est. ≈2.4%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Calecim Professional Professional Serum

CreamScan AI identified a few things to consider before adding Calecim Professional Professional Serum to your skincare routine:

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using Calecim Professional Professional Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of Calecim Professional Professional Serum

Here’s an overview of the pros and cons of Calecim Professional Professional Serum to help you decide if it’s the right choice for your skincare routine:

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing well-suited for oily skin

✅ As part of a routine: A humectant moisturizing enhancement, beneficial for any skin type

✅ Lightweight texture

✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage

⭕ Cons:

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants

Summary: Calecim Professional Professional Serum

Based on the ingredient list analysis, CreamScan AI suggests that Calecim Professional Professional Serum

, when used alone, delivers lightweight, humectant-rich moisturizing that is well-suited for oily skin. As part of a moisturizing routine, it provides a humectant enhancement, beneficial for all skin types.

With its high antioxidant content, Calecim Professional Professional Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.

That said, there are some things about Calecim Professional Professional Serum worth noting.

Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.

📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

Est. % The Estimated % is our algorithm-based assumption about an ingredient's concentration in a formula. Learn more The Estimated % is our algorithm-based assumption about an ingredient's concentration in a formula. Learn more	Ingredient	Origin	Functions
90	Water The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients. Water The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.	Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water.	Formula helper Solvent – a liquid that dissolves other ingredients. Formula helper Solvent – a liquid that dissolves other ingredients.
2.5	Hyaluronic Acid A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin. Hyaluronic Acid A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.	Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic, All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic, All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)	Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Antioxidant, Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging. Antioxidant, Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging. Formula helper Antistatic – reduces electric charge buildup. Viscosity controlling – changes the thickness of a product. Formula helper Antistatic – reduces electric charge buildup. Viscosity controlling – changes the thickness of a product.
2.4	Glycoproteins A broad term indicating a specific type of proteins, most likely of animal origin. Glycoproteins A broad term indicating a specific type of proteins, most likely of animal origin.	Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)	Antioxidant Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging. Antioxidant Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging.
2.3	1,2-Hexanediol A multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula. 1,2-Hexanediol A multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.	Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Preservative, Preservatives prevent the growth of bacteria and fungi in a product. Preservative, Preservatives prevent the growth of bacteria and fungi in a product. Formula helper Solvent – a liquid that dissolves other ingredients. Formula helper Solvent – a liquid that dissolves other ingredients.
2	Soluble Collagen A protein obtained from farm or marine animals. Collagen molecules are too big to penetrate the skin so when they are applied via a skincare product they sit on top of the skin and act as humectant moisturizers. Soluble Collagen A protein obtained from farm or marine animals. Collagen molecules are too big to penetrate the skin so when they are applied via a skincare product they sit on top of the skin and act as humectant moisturizers.	Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)	Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Formula helper Antistatic – reduces electric charge buildup. Film-forming – creates a film to increase wear time. Formula helper Antistatic – reduces electric charge buildup. Film-forming – creates a film to increase wear time.
1.5	Serum Albumin Serum Albumin		Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Formula helper Film-forming – creates a film to increase wear time. Formula helper Film-forming – creates a film to increase wear time.
1.3	Fibronectin Fibronectin

Water

Function:

Origin:

2.5

Hyaluronic Acid

Function:

Origin:

2.4

Glycoproteins

Function:

Origin:

2.3

1,2-Hexanediol

Function:

Origin:

Soluble Collagen

Function:

Origin:

1.5

Serum Albumin

Function:

Origin:

1.3

Fibronectin

Function:

Origin:

Ratings

Hyaluronic Acid

2.5

Soluble Collagen

Serum Albumin

1.5

Benchmark

None

Benchmark

Moisturizing rating

3.0

Ingredient		Est. %	Benchmark Sciense based points to which we compare all humectants and all occlusives in a product to calculate its Humectancy and Occlusivity. Sciense based points to which we compare all humectants and all occlusives in a product to calculate its Humectancy and Occlusivity.	Raiting
Humectancy	All humectants	6	10	6.0
	Hyaluronic Acid A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin. Hyaluronic Acid A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.	2.5
	Soluble Collagen A protein obtained from farm or marine animals. Collagen molecules are too big to penetrate the skin so when they are applied via a skincare product they sit on top of the skin and act as humectant moisturizers. Soluble Collagen A protein obtained from farm or marine animals. Collagen molecules are too big to penetrate the skin so when they are applied via a skincare product they sit on top of the skin and act as humectant moisturizers.	2
	Serum Albumin Serum Albumin	1.5
Occlusivity	All occlusives	0.0	20	0.0
	None
Moisturizing rating				3.0

Ingredient	Est. %	Benchmark According to various studies, a formula made up of 10% humectants will significantly increase skin hydration. Some studies also suggest that any further icrease in the consentration of humectants does not translate inty any more hydration and may even be dehydrating. To achieve maximum Humectancy, the product should have humectants with a total score of 10 and more. According to various studies, a formula made up of 10% humectants will significantly increase skin hydration. Some studies also suggest that any further icrease in the consentration of humectants does not translate inty any more hydration and may even be dehydrating. To achieve maximum Humectancy, the product should have humectants with a total score of 10 and more.	Humectancy
Hyaluronic Acid A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin. Hyaluronic Acid A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.	2.5
Soluble Collagen A protein obtained from farm or marine animals. Collagen molecules are too big to penetrate the skin so when they are applied via a skincare product they sit on top of the skin and act as humectant moisturizers. Soluble Collagen A protein obtained from farm or marine animals. Collagen molecules are too big to penetrate the skin so when they are applied via a skincare product they sit on top of the skin and act as humectant moisturizers.	2
Serum Albumin Serum Albumin	1.5
All humectants	6	10	6

Hyaluronic Acid

2.5

Soluble Collagen

Serum Albumin

1.5

Benchmark

Ingredient	Est. %	Benchmark The most occlusive product possible is 100% petrolatum (hello Vaseline Jelly). According to studies, hovewer, even 10% petrolatum can achieve almost the same mosturizing effect. The occlusive properties of petrolatum are at least twice as superior as other occlusive ingredients. This is why, in order to match the moisturizing efficacy of 10% petrolatum, a product needs to contain at least 20% of other occlusives. Our benchmark for maximum Occlusivity is 20 (and the petrolatum score is always doubled). The most occlusive product possible is 100% petrolatum (hello Vaseline Jelly). According to studies, hovewer, even 10% petrolatum can achieve almost the same mosturizing effect. The occlusive properties of petrolatum are at least twice as superior as other occlusive ingredients. This is why, in order to match the moisturizing efficacy of 10% petrolatum, a product needs to contain at least 20% of other occlusives. Our benchmark for maximum Occlusivity is 20 (and the petrolatum score is always doubled).	Occlusivity
None
All occlusives	0.0	20	0.0

None

Benchmark

Ingredient	Ingredient anti-wrinkle power Shows on a scale of 0-10 how effective an ingredient is at reducing wrinkles. Both the Reported Efficacy of the ingredient and the Strength of Evidence are taken into account. Shows on a scale of 0-10 how effective an ingredient is at reducing wrinkles. Both the Reported Efficacy of the ingredient and the Strength of Evidence are taken into account.	when present at, %	in this formula est. %	Rating
None
Total				0

None

Anti-wrinkle rating

Ingredient	Est. %	Benchmark It differs from one antioxidant ingredient to another, but, on average, the research suggests that topically applied antioxidants are effective in consentrations of 3% or above. Any product with a total antioxidant score of 3 or more is considered to be reach in antioxidants. It differs from one antioxidant ingredient to another, but, on average, the research suggests that topically applied antioxidants are effective in consentrations of 3% or above. Any product with a total antioxidant score of 3 or more is considered to be reach in antioxidants.
Hyaluronic Acid A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin. Hyaluronic Acid A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.	2.5
Glycoproteins A broad term indicating a specific type of proteins, most likely of animal origin. Glycoproteins A broad term indicating a specific type of proteins, most likely of animal origin.	2.4
All antioxidants	4.9	3

Hyaluronic Acid

2.5

Glycoproteins

2.4

Benchmark

Ingredient	Est. %	Benchmark The effective concentration of soothing ingredients varies, but we consider a product rich in soothing ingredients if their estimated concentration is equal to or higher than 5%. The effective concentration of soothing ingredients varies, but we consider a product rich in soothing ingredients if their estimated concentration is equal to or higher than 5%.	Rich in Soothing
None
All soothing	0	5	No

None

Benchmark

Ingredients explained

Water
Est. %	90
Function	Solvent Solvent – a liquid that dissolves other ingredients. Solvent Solvent – a liquid that dissolves other ingredients.
Origin	Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water.

The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.

Hyaluronic Acid
Est. %	2.5
Function	Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Antioxidant, Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging. Antioxidant, Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging. Antistatic, Antistatic – reduces electric charge buildup. Antistatic, Antistatic – reduces electric charge buildup. Viscosity Controlling Viscosity controlling – changes the thickness of a product. Viscosity Controlling Viscosity controlling – changes the thickness of a product.
Origin	Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic, All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic, All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)

A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.

Glycoproteins
Est. %	2.4
Function	Antioxidant Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging. Antioxidant Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging.
Origin	Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)

A broad term indicating a specific type of proteins, most likely of animal origin.

1,2-Hexanediol
Est. %	2.3
Function	Preservative, Preservatives prevent the growth of bacteria and fungi in a product. Preservative, Preservatives prevent the growth of bacteria and fungi in a product. Solvent Solvent – a liquid that dissolves other ingredients. Solvent Solvent – a liquid that dissolves other ingredients.
Origin	Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

A multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.

Soluble Collagen
Est. %	2
Function	Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Antistatic, Antistatic – reduces electric charge buildup. Antistatic, Antistatic – reduces electric charge buildup. Film-Forming Film-forming – creates a film to increase wear time. Film-Forming Film-forming – creates a film to increase wear time.
Origin	Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)

A protein obtained from farm or marine animals. Collagen molecules are too big to penetrate the skin so when they are applied via a skincare product they sit on top of the skin and act as humectant moisturizers.

Serum Albumin
Est. %	1.5
Function	Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Film-Forming Film-forming – creates a film to increase wear time. Film-Forming Film-forming – creates a film to increase wear time.
Origin