Benadryl Extra Strength Anti-Itch Cooling Spray Ingredients + Evidence-Based Efficacy Review

Benadryl Extra Strength Anti-Itch Cooling Spray Ingredients

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Full Ingredient List (INCI):

Alcohol, Glycerin, PVP, Water, Tromethamine, Diphenhydramine HCl, Zinc Acetate

Review

Does Benadryl Extra Strength Anti-Itch Cooling Spray Work?

According to CreamScan's analysis of the ingredient list, here’s what Benadryl Extra Strength Anti-Itch Cooling Spray has to offer:

✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.

Key Benefits of Benadryl Extra Strength Anti-Itch Cooling Spray

These are the key benefits you can expect from using Benadryl Extra Strength Anti-Itch Cooling Spray:

🔵 Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, Benadryl Extra Strength Anti-Itch Cooling Spray is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, entirely due to the high content of Glycerin (est. ≈25.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Benadryl Extra Strength Anti-Itch Cooling Spray

CreamScan identified a few things to consider before adding Benadryl Extra Strength Anti-Itch Cooling Spray to your skincare routine:

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using Benadryl Extra Strength Anti-Itch Cooling Spray as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of Benadryl Extra Strength Anti-Itch Cooling Spray

Here’s an overview of the pros and cons of Benadryl Extra Strength Anti-Itch Cooling Spray to help you decide if it’s the right choice for your skincare routine:

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin

✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type

✅ Lightweight texture

⭕ Cons:

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants

Summary: Benadryl Extra Strength Anti-Itch Cooling Spray

Based on the ingredient list analysis, CreamScan AI suggests that Benadryl Extra Strength Anti-Itch Cooling Spray

, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.

That said, there are some things about Benadryl Extra Strength Anti-Itch Cooling Spray worth noting.

Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.

📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

Est. % The Estimated % is our algorithm-based assumption about an ingredient's concentration in a formula. Learn more The Estimated % is our algorithm-based assumption about an ingredient's concentration in a formula. Learn more	Ingredient	Origin	Functions
50	Alcohol An effective antimicrobial ingredient that kills bacteria, fungi, and even some viruses. It is also an excellent solvent and astringent. Alcohol helps to create lighter and less viscous products. It can, however, be dehydrating and skin-sensitizing. Alcohol An effective antimicrobial ingredient that kills bacteria, fungi, and even some viruses. It is also an excellent solvent and astringent. Alcohol helps to create lighter and less viscous products. It can, however, be dehydrating and skin-sensitizing.	Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Astringent Astringent ingredients provide the skin with a tightened feeling, help to reduce the appearance of large pores, and assist in the healing of small cuts and wounds. Astringent Astringent ingredients provide the skin with a tightened feeling, help to reduce the appearance of large pores, and assist in the healing of small cuts and wounds. Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Formula helper Antifoaming – reduces or prevents the formation of foam. Solvent – a liquid that dissolves other ingredients. Viscosity controlling – changes the thickness of a product. Formula helper Antifoaming – reduces or prevents the formation of foam. Solvent – a liquid that dissolves other ingredients. Viscosity controlling – changes the thickness of a product.
25	Glycerin The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective. Glycerin The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.	Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)	Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Emollient Emollients fill the micro-cracks in the skin and leave it feeling soft and pleasant to the touch. Emollients are often mistakenly perceived as moisturizing ingredients. Emollient Emollients fill the micro-cracks in the skin and leave it feeling soft and pleasant to the touch. Emollients are often mistakenly perceived as moisturizing ingredients. Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Formula helper Denaturant – turns alcohol undrinkable. Solvent – a liquid that dissolves other ingredients. Viscosity controlling – changes the thickness of a product. Formula helper Denaturant – turns alcohol undrinkable. Solvent – a liquid that dissolves other ingredients. Viscosity controlling – changes the thickness of a product.
12	PVP An excellent film-former used in hairsprays, peel-off masks, and even some self-tanning products. These films are strong and hold onto the skin. PVP An excellent film-former used in hairsprays, peel-off masks, and even some self-tanning products. These films are strong and hold onto the skin.	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Formula helper Antistatic – reduces electric charge buildup. Binding – bonds ingredients together. Dispersing – ensures the even distribution of particles. Emulsion stabilizing – increases the stability of a formula. Film-forming – creates a film to increase wear time. Viscosity controlling – changes the thickness of a product. Formula helper Antistatic – reduces electric charge buildup. Binding – bonds ingredients together. Dispersing – ensures the even distribution of particles. Emulsion stabilizing – increases the stability of a formula. Film-forming – creates a film to increase wear time. Viscosity controlling – changes the thickness of a product.
6.8	Water The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients. Water The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.	Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water.	Formula helper Solvent – a liquid that dissolves other ingredients. Formula helper Solvent – a liquid that dissolves other ingredients.
2	Tromethamine An ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level. Tromethamine An ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level.	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Formula helper pH adjuster – alters the pH level of a formula. Formula helper pH adjuster – alters the pH level of a formula.
2 Verified concentration of an ingredient as indicated on its package, in the ingredient list, or on the official website. Verified concentration of an ingredient as indicated on its package, in the ingredient list, or on the official website.	Diphenhydramine HCl Diphenhydramine HCl
0.1 Verified concentration of an ingredient as indicated on its package, in the ingredient list, or on the official website. Verified concentration of an ingredient as indicated on its package, in the ingredient list, or on the official website.	Zinc Acetate Zinc Acetate	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.	Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Astringent Astringent ingredients provide the skin with a tightened feeling, help to reduce the appearance of large pores, and assist in the healing of small cuts and wounds. Astringent Astringent ingredients provide the skin with a tightened feeling, help to reduce the appearance of large pores, and assist in the healing of small cuts and wounds.

Alcohol

Function:

Origin:

Glycerin

Function:

Origin:

PVP

Function:

Origin:

6.8

Water

Function:

Origin:

Tromethamine

Function:

Origin:

Diphenhydramine HCl

Function:

Origin:

0.1

Zinc Acetate

Function:

Origin:

Ratings

Glycerin

Benchmark

None

Benchmark

Moisturizing rating

5.0

Ingredient		Est. %	Benchmark Sciense based points to which we compare all humectants and all occlusives in a product to calculate its Humectancy and Occlusivity. Sciense based points to which we compare all humectants and all occlusives in a product to calculate its Humectancy and Occlusivity.	Raiting
Humectancy	All humectants	25	10	10.0
	Glycerin The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective. Glycerin The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.	25
Occlusivity	All occlusives	0.0	20	0.0
	None
Moisturizing rating				5.0

Ingredient	Est. %	Benchmark According to various studies, a formula made up of 10% humectants will significantly increase skin hydration. Some studies also suggest that any further icrease in the consentration of humectants does not translate inty any more hydration and may even be dehydrating. To achieve maximum Humectancy, the product should have humectants with a total score of 10 and more. According to various studies, a formula made up of 10% humectants will significantly increase skin hydration. Some studies also suggest that any further icrease in the consentration of humectants does not translate inty any more hydration and may even be dehydrating. To achieve maximum Humectancy, the product should have humectants with a total score of 10 and more.	Humectancy
Glycerin The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective. Glycerin The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.	25
All humectants	25	10	10

Glycerin

Benchmark

Ingredient	Est. %	Benchmark The most occlusive product possible is 100% petrolatum (hello Vaseline Jelly). According to studies, hovewer, even 10% petrolatum can achieve almost the same mosturizing effect. The occlusive properties of petrolatum are at least twice as superior as other occlusive ingredients. This is why, in order to match the moisturizing efficacy of 10% petrolatum, a product needs to contain at least 20% of other occlusives. Our benchmark for maximum Occlusivity is 20 (and the petrolatum score is always doubled). The most occlusive product possible is 100% petrolatum (hello Vaseline Jelly). According to studies, hovewer, even 10% petrolatum can achieve almost the same mosturizing effect. The occlusive properties of petrolatum are at least twice as superior as other occlusive ingredients. This is why, in order to match the moisturizing efficacy of 10% petrolatum, a product needs to contain at least 20% of other occlusives. Our benchmark for maximum Occlusivity is 20 (and the petrolatum score is always doubled).	Occlusivity
None
All occlusives	0.0	20	0.0

None

Benchmark

Ingredient	Ingredient anti-wrinkle power Shows on a scale of 0-10 how effective an ingredient is at reducing wrinkles. Both the Reported Efficacy of the ingredient and the Strength of Evidence are taken into account. Shows on a scale of 0-10 how effective an ingredient is at reducing wrinkles. Both the Reported Efficacy of the ingredient and the Strength of Evidence are taken into account.	when present at, %	in this formula est. %	Rating
None
Total				0

None

Anti-wrinkle rating

Ingredient	Est. %	Benchmark It differs from one antioxidant ingredient to another, but, on average, the research suggests that topically applied antioxidants are effective in consentrations of 3% or above. Any product with a total antioxidant score of 3 or more is considered to be reach in antioxidants. It differs from one antioxidant ingredient to another, but, on average, the research suggests that topically applied antioxidants are effective in consentrations of 3% or above. Any product with a total antioxidant score of 3 or more is considered to be reach in antioxidants.	Rich in Antioxidants
None
All antioxidants	0	3	No

None

Benchmark

Ingredient	Est. %	Benchmark The effective concentration of soothing ingredients varies, but we consider a product rich in soothing ingredients if their estimated concentration is equal to or higher than 5%. The effective concentration of soothing ingredients varies, but we consider a product rich in soothing ingredients if their estimated concentration is equal to or higher than 5%.	Rich in Soothing
None
All soothing	0	5	No

None

Benchmark

Ingredients explained

Alcohol
Est. %	50
Function	Antimicrobial, Antimicrobials prevent the growth of harmful microorganisms on the skin. Antimicrobial, Antimicrobials prevent the growth of harmful microorganisms on the skin. Astringent, Astringent ingredients provide the skin with a tightened feeling, help to reduce the appearance of large pores, and assist in the healing of small cuts and wounds. Astringent, Astringent ingredients provide the skin with a tightened feeling, help to reduce the appearance of large pores, and assist in the healing of small cuts and wounds. Fragrance, Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance, Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Antifoaming, Antifoaming – reduces or prevents the formation of foam. Antifoaming, Antifoaming – reduces or prevents the formation of foam. Solvent, Solvent – a liquid that dissolves other ingredients. Solvent, Solvent – a liquid that dissolves other ingredients. Viscosity Controlling Viscosity controlling – changes the thickness of a product. Viscosity Controlling Viscosity controlling – changes the thickness of a product.
Origin	Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

An effective antimicrobial ingredient that kills bacteria, fungi, and even some viruses. It is also an excellent solvent and astringent. Alcohol helps to create lighter and less viscous products. It can, however, be dehydrating and skin-sensitizing.

Glycerin
Est. %	25
Function	Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Emollient, Emollients fill the micro-cracks in the skin and leave it feeling soft and pleasant to the touch. Emollients are often mistakenly perceived as moisturizing ingredients. Emollient, Emollients fill the micro-cracks in the skin and leave it feeling soft and pleasant to the touch. Emollients are often mistakenly perceived as moisturizing ingredients. Fragrance, Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance, Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Denaturant, Denaturant – turns alcohol undrinkable. Denaturant, Denaturant – turns alcohol undrinkable. Solvent, Solvent – a liquid that dissolves other ingredients. Solvent, Solvent – a liquid that dissolves other ingredients. Viscosity Controlling Viscosity controlling – changes the thickness of a product. Viscosity Controlling Viscosity controlling – changes the thickness of a product.
Origin	Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic, All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic, All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

PVP
Est. %	12
Function	Antistatic, Antistatic – reduces electric charge buildup. Antistatic, Antistatic – reduces electric charge buildup. Binding, Binding – bonds ingredients together. Binding, Binding – bonds ingredients together. Dispersing, Dispersing – ensures the even distribution of particles. Dispersing, Dispersing – ensures the even distribution of particles. Emulsion Stabilizing, Emulsion stabilizing – increases the stability of a formula. Emulsion Stabilizing, Emulsion stabilizing – increases the stability of a formula. Film-Forming, Film-forming – creates a film to increase wear time. Film-Forming, Film-forming – creates a film to increase wear time. Viscosity Controlling Viscosity controlling – changes the thickness of a product. Viscosity Controlling Viscosity controlling – changes the thickness of a product.
Origin	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

An excellent film-former used in hairsprays, peel-off masks, and even some self-tanning products. These films are strong and hold onto the skin.

Water
Est. %	6.8
Function	Solvent Solvent – a liquid that dissolves other ingredients. Solvent Solvent – a liquid that dissolves other ingredients.
Origin	Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water.

The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.

Tromethamine
Est. %	2
Function	Fragrance, Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance, Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. pH Adjuster pH adjuster – alters the pH level of a formula. pH Adjuster pH adjuster – alters the pH level of a formula.
Origin	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.

An ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level.

Diphenhydramine HCl
Est. %	2
Function
Origin

Zinc Acetate
Est. %	0.1
Function	Antimicrobial, Antimicrobials prevent the growth of harmful microorganisms on the skin. Antimicrobial, Antimicrobials prevent the growth of harmful microorganisms on the skin. Astringent Astringent ingredients provide the skin with a tightened feeling, help to reduce the appearance of large pores, and assist in the healing of small cuts and wounds. Astringent Astringent ingredients provide the skin with a tightened feeling, help to reduce the appearance of large pores, and assist in the healing of small cuts and wounds.
Origin	Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.