Tetrahydrodiferuloylmethane

An antioxidant turmeric derivative.
Antioxidant
Soothing
Other functions
Origin
Tetrahydrodiferuloylmethane

Overview

Tetrahydrodiferuloylmethane, also known as tetrahydrocurcumin (THC), is an organic antioxidant and soothing compound belonging to the family of curcuminoids.

Curcuminoids make up a major part of turmeric, an Indian medicinal and culinary plant that many are familiar with. Unlike other turmeric derivatives that have a vibrant yellow color, THC is a white powdered extract.

New research suggests that it may have some anti-pigment action on human skin, but further research is necessary to confirm this.

Science

1
Aggarwal BB, Deb L, Prasad S. Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules. 2014 Dec 24;20(1):185-205. doi: 10.3390/molecules20010185. PMID: 25547723; PMCID: PMC6272158.
2
Sandur, S. K., Pandey, M. K., Sung, B., Ahn, K. S., Murakami, A., Sethi, G., … Aggarwal, B. B. (2007). Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis, 28(8), 1765–1773.
3
Goenka, S.; Simon, S.R. Comparative Study of Curcumin and Its Hydrogenated Metabolites, Tetrahydrocurcumin, Hexahydrocurcumin, and Octahydrocurcumin, on Melanogenesis in B16F10 and MNT-1 Cells. Cosmetics 2021, 8, 4. https://doi.org/10.3390/cosmetics8010004