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sh-Polypeptide-1

Also known as Basic Fibroblast Growth Factor. It has collagen and elastin-boosting effects and can result in firmer, more elastic skin. It has been tested for scar healing, but its use in skincare products is still a bit controversial.

Functions
Anti-Wrinkle
Anti-Wrinkle
Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles.
Anti-Wrinkle
Anti-Wrinkle
Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles.
sh-Polypeptide-1

Overview

SH-Polypeptide-1 belongs to the class of human growth factors; this one in particular is a basic fibroblast growth factor which, along with its cousin acidic fibroblast growth factor (SH-Polypeptide 11), tell fibroblasts to produce more structural proteins such as collagen and elastin, making the skin more firm, elastic, and plump.

They also tell the fibroblasts to proliferate (i.e., divide to create more skin cells). This effect is called mitogenic.

The research articles mostly focus on bFGF as a wound healing agent and ingredient for the treatment of badly healed scars. bFGF was tested as an injectable treatment for wrinkles with very good results. When it comes to application as a cream or serum, it must be carefully formulated into liposomes or other delivery systems in order to help it pass through the skin barrier.

The application of growth factors to the skin is a controversial topic, but so far there are no proven negative side effects.

Science

1
De Araújo, R., Lôbo, M., Trindade, K., Silva, D. F., & Pereira, N. (2019). Fibroblast Growth Factors: A Controlling Mechanism of Skin Aging. Skin Pharmacology and Physiology, 1–8.
2
Tiede, S., Ernst, N., Bayat, A., Paus, R., Tronnier, V., & Zechel, C. (2009). Basic fibroblast growth factor: a potential new therapeutic tool for the treatment of hypertrophic and keloid scars. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 191(1), 33–44.
3
Kamakura, T., et al. (2015). Platelet-Rich Plasma with Basic Fibroblast Growth Factor for Treatment of Wrinkles and Depressed Areas of the Skin. Plastic and reconstructive surgery, 136(5), 931–939.
4
Choi, et al. (2018). Preparation and In Vitro Evaluation of Elastic Nanoliposomes for Topical Delivery of Highly Skin-Permeable Growth Factors. Journal of nanoscience and nanotechnology, 18(2), 887–892.