Retinyl Retinoate

A retinoid with modest, yet proven by one study, anti-wrinkle efficacy.

Anti-wrinkle
Origin
Retinyl Retinoate

Overview

a retinoid with modest, yet proven by one study, anti-wrinkle efficacy.

Ratings

Reported efficacy
3
Wrinkle reduction
-6%
vs. benchmark (Tretinoin 0.05%)
-18%
Strength of evidence
5
Study 1
5
Study 2
-
Anti-wrinkle power
1.5
Creamscan anti-wrinkle rating is a weighted result of 2 parts:
1
Reported Efficacy: This measures the ingredient's ability to reduce wrinkles, confirmed by a double-blind, vehicle-controlled, randomized study. We compare the results reported in the study against a gold standard anti-wrinkle benchmark, 0.05% Tretinoin, to calculate a 0-10 efficacy score for the reviewed ingredient.
2
Strength of Evidence: This reflects how thoroughly an ingredient has been researched. While there are many studies on cosmetic ingredients, very few are robust, vehicle-controlled clinical trials on humans.
Each study meeting CreamScan Research Evaluation Standards earns the ingredient 5 points. An ingredient with just one qualifying study receives a score of 5 out of 10 for Strength of Evidence. To achieve a perfect score of 10 out of 10, an ingredient must have at least two studies confirming its efficacy from different research teams.

Science

1
Kim et al. Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial. Br J Dermatol. 2010 Mar;162(3):497-502. PMID: 19849696