a retinoid with modest, yet proven by one study, anti-wrinkle efficacy.
Ratings
Reported efficacy
3
Wrinkle reduction
A lotion containing 0.06% retinyl retinoate reduced the mean photodamage score of periorbital wrinkles by 6% after 12 weeks of use compared to vehicle treatment. Evaluated by dermatologists on a 0 to 7 point scale in a study involving 24 subjects (study 1).
A lotion containing 0.06% retinyl retinoate reduced the mean photodamage score of periorbital wrinkles by 6% after 12 weeks of use compared to vehicle treatment. Evaluated by dermatologists on a 0 to 7 point scale in a study involving 24 subjects (study 1).
-6%
vs. benchmark (Tretinoin 0.05%)
A cream containing 0.05% Tretinoin (Retinoic acid) showed an 18% decrease in the mean baseline grade of fine wrinkling compared to the vehicle after 24 weeks of use, as measured by investigators on a 0 to 9 point scale. Study involving 299 subjects.
Weinstein et al. Topical tretinoin for treatment of photodamaged skin. A multicenter study. Arch Dermatol. 1991 May;127(5):659-65. PMID: 2024983
A cream containing 0.05% Tretinoin (Retinoic acid) showed an 18% decrease in the mean baseline grade of fine wrinkling compared to the vehicle after 24 weeks of use, as measured by investigators on a 0 to 9 point scale. Study involving 299 subjects.
Weinstein et al. Topical tretinoin for treatment of photodamaged skin. A multicenter study. Arch Dermatol. 1991 May;127(5):659-65. PMID: 2024983
-18%
Strength of evidence
5
Study 1
Kim et al. Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial. Br J Dermatol. 2010 Mar;162(3):497-502. PMID: 19849696
Kim et al. Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial. Br J Dermatol. 2010 Mar;162(3):497-502. PMID: 19849696
Creamscan anti-wrinkle rating is a weighted result of 2 parts:
1
Reported Efficacy: This measures the ingredient's
ability to reduce wrinkles, confirmed by a double-blind, vehicle-controlled, randomized study. We compare the results reported in the study against a gold standard anti-wrinkle
benchmark, 0.05% Tretinoin, to calculate a 0-10 efficacy score for the reviewed
ingredient.
2
Strength of Evidence: This reflects how thoroughly
an ingredient has been researched. While there are many studies on cosmetic ingredients,
very few are robust, vehicle-controlled clinical trials on humans.
Each study meeting
CreamScan Research Evaluation Standards
earns the ingredient 5 points. An ingredient with just one qualifying study receives
a score of 5 out of 10 for Strength of Evidence. To achieve a perfect score of 10 out
of 10, an ingredient must have at least two studies confirming its efficacy from different
research teams.
Science
1
Kim et al. Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial. Br J Dermatol. 2010 Mar;162(3):497-502. PMID: 19849696