Retinoic Acid

AKA: Tretinoin
Also-Known-As:
Tretinoin
Anti-wrinkle
Other functions
Origin
Retinoic Acid

Overview

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Ratings

Reported efficacy
10
Wrinkle reduction
-15%
vs. benchmark (Tretinoin 0.05%)
-15%
Strength of evidence
10
Study 1
5
Study 2
5
Anti-wrinkle power
10
Creamscan anti-wrinkle rating is a weighted result of 2 parts:
1
Reported Efficacy: This measures the ingredient's ability to reduce wrinkles, confirmed by a double-blind, vehicle-controlled, randomized study. We compare the results reported in the study against a gold standard anti-wrinkle benchmark, 0.05% Tretinoin, to calculate a 0-10 efficacy score for the reviewed ingredient.
2
Strength of Evidence: This reflects how thoroughly an ingredient has been researched. While there are many studies on cosmetic ingredients, very few are robust, vehicle-controlled clinical trials on humans.
Each study meeting CreamScan Research Evaluation Standards earns the ingredient 5 points. An ingredient with just one qualifying study receives a score of 5 out of 10 for Strength of Evidence. To achieve a perfect score of 10 out of 10, an ingredient must have at least two studies confirming its efficacy from different research teams.

Science

1
Grove et al. Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream. J Am Acad Dermatol. 1991 Aug;25(2 Pt 1):231-7. PMID: 1918458
2
Weinstein et al. Topical tretinoin for treatment of photodamaged skin. A multicenter study. Arch Dermatol. 1991 May;127(5):659-65. PMID: 2024983