Retinal

AKA: retinaldehyde

A potent ingredient of the retinoid group with confirmed anti-wrinkle capabilities.

Also-Known-As:
retinaldehyde
Anti-wrinkle
Origin
Retinal

Overview

A potent ingredient of the retinoid group with confirmed anti-wrinkle capabilities.

Ratings

Reported efficacy
5
Wrinkle reduction
-8%
vs. benchmark (Tretinoin 0.05%)
-15%
Strength of evidence
10
Study 1
5
Study 2
5
Anti-wrinkle power
5
Creamscan anti-wrinkle rating is a weighted result of 2 parts:
1
Reported Efficacy: This measures the ingredient's ability to reduce wrinkles, confirmed by a double-blind, vehicle-controlled, randomized study. We compare the results reported in the study against a gold standard anti-wrinkle benchmark, 0.05% Tretinoin, to calculate a 0-10 efficacy score for the reviewed ingredient.
2
Strength of Evidence: This reflects how thoroughly an ingredient has been researched. While there are many studies on cosmetic ingredients, very few are robust, vehicle-controlled clinical trials on humans.
Each study meeting CreamScan Research Evaluation Standards earns the ingredient 5 points. An ingredient with just one qualifying study receives a score of 5 out of 10 for Strength of Evidence. To achieve a perfect score of 10 out of 10, an ingredient must have at least two studies confirming its efficacy from different research teams.

Science

1
Creidi et al. Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment. J Am Acad Dermatol. 1998 Dec;39(6):960-5. PMID: 9843009
2
Kim et al. The efficacy and safety of multilamellar vesicle containing retinaldehyde: A double-blinded, randomized, split-face controlled study. J Cosmet Dermatol. 2021 Sep;20(9):2874-2879. PMID: 33569865