A potent ingredient of the retinoid group with confirmed anti-wrinkle capabilities.
Ratings
Reported efficacy
5
Wrinkle reduction
A cream containing 0.05% retinal (retinaldehyde) resulted in an 8% decrease in the average maximum wrinkle depth (Rz) of facial fine wrinkles compared to the vehicle after 18 weeks of use. Measured instrumentally using optical profilometry with skin surface replicas in a study involving 125 subjects (study 1).
A cream containing 0.05% retinal (retinaldehyde) resulted in an 8% decrease in the average maximum wrinkle depth (Rz) of facial fine wrinkles compared to the vehicle after 18 weeks of use. Measured instrumentally using optical profilometry with skin surface replicas in a study involving 125 subjects (study 1).
-8%
vs. benchmark (Tretinoin 0.05%)
A cream containing 0.05% Tretinoin (Retinoic acid) showed a 15% decrease in average skin roughness (Ra) and a 15% decrease in average maximum wrinkle depth (Rz) compared to the vehicle after 24 weeks of use. Measured instrumentally (optical profilometry using skin surface replicas) on cheek wrinkles. Study involving 299 subjects.
Grove et al. Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream. J Am Acad Dermatol. 1991 Aug;25(2 Pt 1):231-7. PMID: 1918458
A cream containing 0.05% Tretinoin (Retinoic acid) showed a 15% decrease in average skin roughness (Ra) and a 15% decrease in average maximum wrinkle depth (Rz) compared to the vehicle after 24 weeks of use. Measured instrumentally (optical profilometry using skin surface replicas) on cheek wrinkles. Study involving 299 subjects.
Grove et al. Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream. J Am Acad Dermatol. 1991 Aug;25(2 Pt 1):231-7. PMID: 1918458
-15%
Strength of evidence
10
Study 1
Creidi et al. Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment. J Am Acad Dermatol. 1998 Dec;39(6):960-5. PMID: 9843009
Creidi et al. Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment. J Am Acad Dermatol. 1998 Dec;39(6):960-5. PMID: 9843009
5
Study 2
Kim et al. The efficacy and safety of multilamellar vesicle containing retinaldehyde: A double-blinded, randomized, split-face controlled study. J Cosmet Dermatol. 2021 Sep;20(9):2874-2879. PMID: 33569865
Kim et al. The efficacy and safety of multilamellar vesicle containing retinaldehyde: A double-blinded, randomized, split-face controlled study. J Cosmet Dermatol. 2021 Sep;20(9):2874-2879. PMID: 33569865
5
Anti-wrinkle power
5
Creamscan anti-wrinkle rating is a weighted result of 2 parts:
1
Reported Efficacy: This measures the ingredient's
ability to reduce wrinkles, confirmed by a double-blind, vehicle-controlled, randomized study. We compare the results reported in the study against a gold standard anti-wrinkle
benchmark, 0.05% Tretinoin, to calculate a 0-10 efficacy score for the reviewed
ingredient.
2
Strength of Evidence: This reflects how thoroughly
an ingredient has been researched. While there are many studies on cosmetic ingredients,
very few are robust, vehicle-controlled clinical trials on humans.
Each study meeting
CreamScan Research Evaluation Standards
earns the ingredient 5 points. An ingredient with just one qualifying study receives
a score of 5 out of 10 for Strength of Evidence. To achieve a perfect score of 10 out
of 10, an ingredient must have at least two studies confirming its efficacy from different
research teams.
Science
1
Creidi et al. Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment. J Am Acad Dermatol. 1998 Dec;39(6):960-5. PMID: 9843009
2
Kim et al. The efficacy and safety of multilamellar vesicle containing retinaldehyde: A double-blinded, randomized, split-face controlled study. J Cosmet Dermatol. 2021 Sep;20(9):2874-2879. PMID: 33569865