Proline

The best humectant moisturizer of all the amino acids. It is a part of the skin's Natural Moisturizing Factor and increases hydration in the top layers of the skin. It also has antioxidant activity and helps to heal damaged skin.
Moisturizing
Origin
Proline

Overview

Proline is an essential amino acid and one of the most important building blocks of collagen. It is a particularly good humectant moisturizing ingredient, able to retain more water than any other amino acid. It also has antioxidant activity and is able to decrease UV-induced oxidation of skin lipids.

Adding proline to a skincare formula may help to improve the healing of damaged skin and small cuts and wounds, simply because it can travel through the damaged skin and take part in the synthesis of the new collagen. The same study showed, however, that the oral intake of proline is even more effective than the topical application.

Science

1
Oshimura, E., & Sakamoto, K. (2017). Amino Acids, Peptides, and Proteins. Cosmetic Science and Technology, 285–303.
2
Aydin, H., et al. (2019). The Effects of Local and Systemic Administration of Proline on Wound Healing in Rats. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 32(6), 523–529.