Potassium Azeloyl Diglycinate

A modified version of azelaic acid. It reduces signs of redness, hyperpigmentation, and stinging and burning, and is better tolerated, more effective, and more easily incorporated into creams than azelaic acid.
Soothing
Other functions
Potassium Azeloyl Diglycinate

Overview

Potassium azeloyl glycinate is a modified version of azelaic acid, a soothing, anti-inflammatory, and anti-redness ingredient.

When compared to azelaic acid, Potassium azeloyl glycinate is better tolerated, more effective in low concentrations, and has better solubility in water (whereas azelaic acid is notoriously difficult to incorporate into skincare products).

It is used in the treatment of skin diseases such as rosacea, with clinical studies reporting very good results against redness, stinging, and burning – an up to 50% reduction.

In regular skincare products, this ingredient is also effective against dark pigment spots, freckles, or melasma, as suggested by another study. Another study on a small number of volunteers indicates its strong effects on the skin's oil levels (reduced by around 30%).

Science

1
Berardesca, E., et al. (2012). Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea. Journal of cosmetic dermatology, 11(1), 37–41.
2
Veraldi, S., et al. (2015). Treatment of symptoms of erythemato-telangiectatic rosacea with topical potassium azeloyl diglycinate and hydroxypropyl chitosan: Results of a sponsor-free, multicenter, open study. The Journal of dermatological treatment, 26(2), 191–192.
3
Viyoch, J., et al. (2010). Effects of trans-4-(aminomethyl) cyclohexanecarboxylic acid/potassium azeloyl diglycinate/niacinamide topical emulsion in Thai adults with melasma: a single-center, randomized, double-blind, controlled study. Current therapeutic research, clinical and experimental, 71(6), 345–359.
4
Rigano, Luigi & Cucchiara, M.. (2003). Azeloyl-Glycine: A new active in skin disequilibrium. Journal of Applied Cosmetology. 21. 177-188.