Phenylalanine

An essential amino acid used in the treatment of vitiligo and other pigmentation issues. It is considered less effective than other anti-pigment ingredients and is often used in combination with them.
Functions
Origin
Phenylalanine

Overview

Phenylalanine is an essential amino acid that is used by our body to create proteins.

It was used in dermatology in the past as a part of vitiligo treatment (in combination with other topical agents and/or UV light therapy) but nowadays the ingredient is considered to be less effective.

A modified version of Phenylalanine, Undecylenoyl phenylalanine (with undecylenic acid for better fat solubility), is used as a prospective anti-pigment treatment for dark spots and melasma. It is said to have a slightly pungent aroma.

Science

1
Hossani-Madani, A. R., & Halder, R. M. (2010). Topical treatment and combination approaches for vitiligo: new insights, new developments. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 145(1), 57–78.
2
Katoulis, A., et al. (2014). A double-blind vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of melasma in females. Journal of cosmetic dermatology, 13(2), 86–90.