A small synthetic peptide that signals the skin to produce more collagen. It has been clinically tested and proven to reduce skin roughness and the appearance of wrinkles.
Palmitoyl Tripeptide-5, previously known as Palmitoyl Tripeptide-3, or by its trade name Syn®-Coll, is a synthetic signal peptide consisting of three amino acids (Arg-Phe-Lys) with palmitic acid on one end for better oil solubility and skin absorption.
It has been created to mimic Thrombospondin I, a skin signal protein that binds to tissue growth factor beta (TGF-ß). Syn-Coll activates TGF-ß and starts a signal cascade which results in an increased production of collagen at the end. Several test-tube experiments confirm this theory.
It has also been tested on volunteers – 60 Chinese volunteers had a 2.5% cream applied over a period of 84 days and reported reduced skin roughness and anti-wrinkle effects. According to the manufacturer, the ingredient may also help with stretch marks.
'%20fill='black'/%3e%3c/svg%3e)
