A short, synthetically made peptide similar to elastin fragments. It works as a signal peptide, stimulating the growth of skin cells and facilitating skin repair. It has been tested mostly in test-tube experiments so far.
Antioxidant
Antioxidant
Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging.
Antioxidant
Antioxidants reduce the oxidative stress caused by free radicals and prevent accelerated skin aging.
Other functions
Anti-Wrinkle
Anti-Wrinkle
Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles.
Anti-Wrinkle
Anti-Wrinkle
Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles.
Origin
Botanical,
Botanical
Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials.
Botanical,
Botanical
Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials.
Synthetic,
Synthetic
All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.
Synthetic,
Synthetic
All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.
Animal
Animal
Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)
Animal
Animal
Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.)
Palmitoyl Hexapeptide-12 is a short peptide consisting of six amino acids: Val-Gly-Val-Ala-Pro-Gly, with palmitic acid on one end to enhance its lipid solubility. This amino acid sequence can be found many times in elastin, one of the main structural proteins of our skin.
Hexapeptide-12 functions as a signal molecule in the dermis, stimulating the growth of fibroblasts, as well as the restructuring and repair of the skin.
The manufacturer trademarked this ingredient under the name Biopeptide-EL as an anti-aging and anti-wrinkle ingredient. So far, this claim has been supported by two test-tube experiments and by a small clinical trial by the manufacturer with a 4% cream.
Science
1
Zhang, L., & Falla, T. J. (2009). Cosmeceuticals and peptides. Clinics in Dermatology, 27(5), 485–494.
2
Tajima, S., Wachi, H., Uemura, Y., & Okamoto, K. (1997). Modulation by elastin peptide VGVAPG of cell proliferation and elastin expression in human skin fibroblasts. Archives of Dermatological Research, 289(8), 489–492.
3
Attia-Vigneau, J., Terryn, C., Lorimier, S., Sandre, J., Antonicelli, F., & Hornebeck, W. (2014). Regeneration of Human Dermis by a Multi-Headed Peptide. Journal of Investigative Dermatology, 134(1), 58–67.
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