Histidine

A humectant moisturizing amino acid with weak antioxidant effects that is a part of the skin’s Natural Moisturizing Factor. It can attract water to the skin’s surface and is slightly alkaline, thereby helping to balance a product's pH.
Moisturizing
Other functions
Origin
Histidine

Overview

Histidine is an essential amino acid (meaning the human body cannot make it on its own).

It is used in skincare products for its humectant moisturizing properties and as a pH-controlling ingredient, since it's slightly alkaline. It has an antioxidant activity that allows it to fish out reactive oxygen species. Although compared to other antioxidants, this activity is fairly weak.

Even though histidine plays many important roles in skin metabolism and structural proteins, the topical application doesn't help much because it is water-soluble and so not absorbed into the deeper layers of the skin.

Science

1
Oshimura, E., & Sakamoto, K. (2017). Amino Acids, Peptides, and Proteins. Cosmetic Science and Technology, 285–303.