Glycyrrhetinic Acid

A compound derived from licorice root. It is a powerful anti-inflammatory ingredient with some anti-pigment properties.
Soothing
Other functions
Origin
Glycyrrhetinic Acid

Overview

Glycyrrhetinic acid is a bioactive plant compound derived from licorice root (Glycyrrhiza glabra root).

It is used in skincare for the same purpose as the whole licorice extract – it is a powerful anti-inflammatory and soothing ingredient used to treat dry and itchy skin, eczema, atopic dermatitis, or psoriasis. It also has some anti-pigment properties and can slow down the production and distribution of melanin in the skin.

It is very similar to the main active ingredient of licorice – glycyrrhizic acid – and is formed in the human body after the ingestion of glycyrrhizic acid. The enzymes in the small intestine chop off the sugar molecules, leaving only the active part of the molecule (which very much resembles steroid hormones).

Read more about licorice root and its uses in skincare here: Glycyrrhiza Glabra (Licorice) Root Extract.

Science

1
Kowalska, A., & Kalinowska‐Lis, U. (2019). 18 β ‐Glycyrrhetinic acid: its core biological properties and dermatological applications. International Journal of Cosmetic Science.