Dipalmitoyl Hydroxyproline

An amino acid derivative. It helps with skin moisturization and may have wrinkle-reducing effects.
Functions
Origin
Dipalmitoyl Hydroxyproline

Overview

Dipalmitoyl Hydroxyproline is an ingredient derived from amino acid proline and common fatty acid palmitic acid.

Hydroxyproline forms an integral part of the collagen in our skin, maintaining its structure and stability. But, because it is such a small, water-soluble amino acid, it is almost impossible to get it to the deeper layers of skin from the surface. Palmitic acid is added to its molecule as a way to increase its solubility in oils and help with absorption.

As for the effects of Dipalmitoyl Hydroxyproline, so far we only have the manufacturer's small clinical test (involving only 15-20 volunteers). They claim that 1% Dipalmitoyl Hydroxyproline after 28 days of application improved the microrelief and moisturization of the skin and reduced the number of crow's feet wrinkles. After 42 days of application, they claim that it caused a 16% reduction in the number of wrinkles.

These results, however, haven't been confirmed by any other independent research so far.

A different derivative of Hydroxyproline, N-acetyl Hydroxyproline, has been found to be effective at treating the dry skin caused by atopic dermatitis. There is therefore still a chance for Dipalmitoyl Hydroxyproline to prove itself as a good anti-aging ingredient.

Science

1
https://www.seppic.com/en/sepilift-dphp
2
http://kingdomofyork.com/skinsnob/SEPILIFT%20DPHP.pdf
3
Hashizume, E., Nakano, T., Kamimura, A., & Morishita, K. (2013). Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritus. Clinical, cosmetic and investigational dermatology, 6, 43–49. https://doi.org/10.2147/CCID.S39370