A synthetically made peptide that was designed to emulate the skin growth factor. It is said to boost the production of the skin's structural elements and the dermo-epidermal junction, although this has not been independently tested.
Caprooyl Tetrapeptide-3 is a synthetically made tetrapeptide from the group of signal peptides.
Its structure consists of four amino acids (lysine, glycine, histidine, and another lysine) with a caproic acid on one end to enhance its solubility in oils and, therefore, enhance its transfer through the skin’s lipid matrix into the deeper layers of the skin. This structure was selected to emulate a growth factor.
This ingredient is trademarked under the name ChroNOline™ and is marketed as an anti-aging ingredient.
According to the manufacturer’s brochure, it works by increasing the production of collagen VII, laminin-5, and fibronectin in the thin, but very important layer of tissue that connects the epidermis and dermis (the dermo-epidermal junction or DEJ). This tissue layer is wavy in young skin, with the waves being held together by collagen strands. When the collagen strands give up or break during aging, the epidermis caves, resulting in wrinkles.
The manufacturer of Caprooyl Tetrapeptide-3 claims that by boosting the production of its building blocks, the ingredient might help to repair the DEJ, thereby reducing the appearance of wrinkles and stretch marks.
Unfortunately, aside from the manufacturer’s information, there is no other independent study that can confirm or disprove this claim.
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