Acetyl Tetrapeptide-5

A synthetically made peptide that was designed to reduce puffy eyebags by regulating the water balance between blood vessels and the skin. It has not been independently tested yet.
Acetyl Tetrapeptide-5


Acetyl Tetrapeptide-5 is a synthetically manufactured peptide from the group of signal peptides, consisting of four amino acids (alanine, two histidines, and a serine) with an acetyl group on one end of the chain.

It is trademarked under the name EYESERYL® and, according to the manufacturer, reduces oedema around the eyes by affecting blood vessels. It is supposed to improve the water balance between blood vessels and skin tissue, thereby helping to remove the excess water that creates puffy eyebags. It is said to do so by constricting blood vessels in a similar way to ACE inhibitors (a group of blood pressure medications).

Unfortunately, there are no other independent studies to prove or disprove this claim. The only information we have so far comes from the manufacturer themselves, which puts Acetyl Tetrapeptide-5 among the less-researched skincare peptides.

Future research should look into the ingredient’s precise mechanism of action, as well as its ability to travel through the skin’s lipid barrier.


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Silke Karin Schagen. Topical Peptide Treatments with EffectiveAnti-Aging Results. Cosmetics 2017,4, 16